由氢化钠-碘化钠复合物对卤代芳烃进行加氢脱卤反应。
Hydrodehalogenation of Haloarenes by a Sodium Hydride-Iodide Composite.
机构信息
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
出版信息
Angew Chem Int Ed Engl. 2017 Feb 6;56(7):1840-1844. doi: 10.1002/anie.201611495. Epub 2017 Jan 10.
PMID:28071853
Abstract
A simple protocol for hydrodebromination and -deiodination of halo(hetero)arenes was enabled by sodium hydride (NaH) in the presence of lithium iodide (LiI). Mechanistic studies showed that an unusual concerted nucleophilic aromatic substitution operates in the present process.
摘要
在氢化钠（NaH）和碘化锂（LiI）存在的条件下，提出了一种简单的卤（杂）芳环氢脱卤和脱碘的方法。机理研究表明，在这个过程中存在一种不寻常的协同亲核芳香取代反应。
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