酰胺导向的氢化钠/碘化钠复合体系引发的 C-H 钠化反应。
Amide-Directed C-H Sodiation by a Sodium Hydride/Iodide Composite.
机构信息
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
出版信息
Angew Chem Int Ed Engl. 2017 Jun 1;56(23):6544-6547. doi: 10.1002/anie.201702512. Epub 2017 Apr 27.
PMID:28449253
Abstract
A new protocol for amide-directed ortho and lateral C-H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds.
摘要
通过氢化钠（NaH）在碘化钠（NaI）或碘化锂（LiI）的存在下，实现了酰胺导向的邻位和间位 C-H 取代的新方法。瞬态有机钠中间体可以转化为功能化的芳族化合物。
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