Department of Biology and Ecology, Faculty of Science, University of Novi Sad, Trg Dositeja Obradovića 2, Novi Sad 21000, Serbia.
Department of Biology and Ecology, Faculty of Science, University of Novi Sad, Trg Dositeja Obradovića 2, Novi Sad 21000, Serbia.
Harmful Algae. 2016 May;55:66-76. doi: 10.1016/j.hal.2016.02.007. Epub 2016 Mar 1.
Cyanobacteria can produce toxic metabolites known as cyanotoxins. Common and frequently investigated cyanotoxins include microcystins (MCs), nodularin (NOD) and saxitoxins (STXs). During the summer of 2011 extensive cyanobacterial growth was found in several fishponds in Serbia. Sampling of the water and fish (common carp, Cyprinus carpio) was performed. Water samples from 13 fishponds were found to contain saxitoxin, microcystin, and/or nodularin. LC-MS/MS showed that MC-RR was present in samples of fish muscle tissue. Histopathological analyses of fish grown in fishponds with cyanotoxin production showed histopathological damage to liver, kidney, gills, intestines and muscle tissues. This study is among the first so far to report severe hyperplasia of intestinal epithelium and severe degeneration of muscle tissue of fish after cyanobacterial exposure. These findings emphasize the importance of cyanobacterial and cyanotoxin monitoring in fishponds in order to recognize cyanotoxins and their potential effects on fish used for human consumption and, further, on human health.
蓝藻可以产生有毒的代谢物，称为蓝藻毒素。常见且经常被研究的蓝藻毒素包括微囊藻毒素（MCs）、节球藻毒素（NOD）和石房蛤毒素（STXs）。2011 年夏天，塞尔维亚的几个鱼塘中发现了大量蓝藻生长。对水和鱼（鲤鱼，Cyprinus carpio）进行了采样。发现来自 13 个鱼塘的水样中含有石房蛤毒素、微囊藻毒素和/或节球藻毒素。LC-MS/MS 显示，MC-RR 存在于鱼肌肉组织样本中。对在有蓝藻毒素产生的鱼塘中生长的鱼进行的组织病理学分析显示，肝脏、肾脏、鳃、肠道和肌肉组织都有组织病理学损伤。这项研究是迄今为止首批报告在暴露于蓝藻后鱼的肠道上皮严重增生和肌肉组织严重退化的研究之一。这些发现强调了在鱼塘中监测蓝藻和蓝藻毒素的重要性，以便识别出蓝藻毒素及其对用于人类消费的鱼类的潜在影响，以及对人类健康的潜在影响。
