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气候变化在改变肝脏健康图谱中的作用。

Role of Climate Change in Changing Hepatic Health Maps.

机构信息

Department of Environmental and Occupational Medicine, Environment and Climate Change Research Institute, National Research Centre, El-Buhouth Street, Cairo, Dokki, Egypt.

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt.

出版信息

Curr Environ Health Rep. 2022 Jun;9(2):299-314. doi: 10.1007/s40572-022-00352-w. Epub 2022 Apr 28.

Abstract

PURPOSE OF REVIEW

Climate change (CC) is currently responsible for global weather extremes. These weather extremes could contribute to changes in the pattern of health problems. The purpose of this review is to discuss the role of CC on remapping of hepatic diseases and the mechanisms of re-mapping.

RECENT FINDINGS

CC was found to have a major influence on the distribution and severity of hepatic diseases, such as outbreaks of vector-borne, water or food-borne, parasitic diseases, re-emerging of disappeared diseases, or emerging of new forms of infectious agents. Migration of infected people from endemic areas due to the CC disasters results in rapid dissemination of infectious diseases that leads to outbreaks or endemicity of diseases in new areas. CC could cause increasing chemical emissions, or change in its biodegradability, or restriction in its dispersion, such as PM, PAHs, heavy metals, mycotoxins, and aquatic toxins. Increase in the concentrations of these chemicals may have significant impacts in changing the health map of hepatic toxicity and liver cancer. The current review confirms the role of CC in changing the pattern of several liver health problems and remapping of these problems in several regions of the world. This review could be of high importance to the health decision-makers as an early alarm and prediction of hepatic health problems with the projected CC.

摘要

目的综述:气候变化(CC)是当前全球极端天气的主要成因。这些极端天气可能会导致健康问题模式发生变化。本综述旨在讨论 CC 对肝脏疾病重新定位的作用以及重新定位的机制。

最新发现:CC 对肝脏疾病的分布和严重程度有重大影响,例如虫媒、水媒或食物源传染病的爆发、已消失疾病的再现或新形式传染病原体的出现。由于 CC 灾害,受感染人群从流行地区迁移,导致传染病迅速传播,导致新地区的疾病爆发或流行。CC 可能导致化学排放物增加,或其生物降解性发生变化,或其分散性受到限制,如 PM、多环芳烃、重金属、霉菌毒素和水生毒素。这些化学物质浓度的增加可能会对改变肝脏毒性和肝癌的健康图谱产生重大影响。本综述证实了 CC 在改变世界几个地区几种肝脏健康问题的模式以及这些问题的重新定位方面的作用。这一综述对于卫生决策者来说可能具有重要意义,因为它可以提前发出关于与 CC 相关的肝脏健康问题的警报和预测。

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