González-Estecha Montserrat, Palazón-Bru Irene, Bodas-Pinedo Andrés, Trasobares Elena, Palazón-Bru Antonio, Fuentes Manuel, Cuadrado-Cenzual M Ángeles, Calvo-Manuel Elpidio
Laboratory Medicine Department, Hospital Clínico San Carlos, Madrid, Spain.
Laboratory Medicine Department, Hospital Clínico San Carlos, Madrid, Spain.
J Trace Elem Med Biol. 2017 Sep;43:93-105. doi: 10.1016/j.jtemb.2016.12.002. Epub 2017 Jan 3.
Several studies have shown an inverse relationship between selenium status and cardiovascular health, although epidemiologic evidence yielded by the randomized trials did not find a beneficial effect of selenium administration. The aim of this study was to analyze the association between serum selenium levels and lipid profile adjusted by age, sex and other associated factors among a general adult population in Spain.
We recruited 372 hospital employee volunteers (60 men and 312 women) with a mean age of 47 (SD: 10.9), whom were given a standardized questionnaire. Serum selenium concentration was measured by electrothermal atomization atomic absorption spectrometry. Serum copper and zinc concentrations were measured using flame atomic absorption spectrometry.
The mean of serum selenium was 79.5μg/L (SD: 11.7) with no sex-dependent differences. In the multivariate linear regression analysis, the associated factors with the mean levels of selenium were: age (β=0.223; CI 95%: 0.101-0.345), p<0.001; widowhood (β=-9.668; CI 95%: -17.234 to -2.102), p=0.012; calcium supplements (β=3.949; CI 95%: 0.059-7.838), p=0.047; zinc (β=0.126; CI 95%: 0.013-0.238), p=0.028 and glucose (β=0.172; CI 95%: 0.062- 0.281), p=0.002; Participants with serum selenium≥79.5μg/L were 1.98 (OR=1.98; CI 95% 1.17-3.35; p=0.011) and 2.04 times (OR=2.04; CI 95% 1.06-3.97; p=0.034) more likely to have cholesterol ≥200mg/dL and LDL-c ≥100mg/dL respectively than those with serum selenium <79.5μg/L.
Higher selenium was positively associated with increased total and LDL cholesterol but not with HDL-c and triglycerides. More studies are needed in order to confirm the lower serum selenium findings in widows.
多项研究表明硒水平与心血管健康呈负相关，尽管随机试验得出的流行病学证据未发现补充硒有有益效果。本研究的目的是分析西班牙普通成年人群中血清硒水平与经年龄、性别及其他相关因素校正后的血脂谱之间的关联。
我们招募了372名医院员工志愿者（60名男性和312名女性），平均年龄为47岁（标准差：10.9），并给他们发放了标准化问卷。采用电热原子吸收光谱法测定血清硒浓度。采用火焰原子吸收光谱法测定血清铜和锌浓度。
血清硒的平均值为79.5μg/L（标准差：11.7），无性别差异。在多元线性回归分析中，与硒平均水平相关的因素有：年龄（β=0.223；95%置信区间：0.101-0.345），p<0.001；丧偶（β=-9.668；95%置信区间：-17.234至-2.102），p=0.012；补钙（β=3.949；95%置信区间：0.059-7.838），p=0.047；锌（β=0.126；95%置信区间：0.013-0.238），p=0.028；以及葡萄糖（β=0.172；95%置信区间：0.062-0.281），p=0.002；血清硒≥79.5μg/L的参与者胆固醇≥200mg/dL和低密度脂蛋白胆固醇≥100mg/dL的可能性分别比血清硒<79.5μg/L的参与者高1.98倍（比值比=1.98；95%置信区间1.17-3.35；p=0.011）和2.04倍（比值比=2.04；95%置信区间1.06-3.97；p=0.034）。
较高的硒水平与总胆固醇和低密度脂蛋白胆固醇升高呈正相关，但与高密度脂蛋白胆固醇和甘油三酯无关。需要更多研究来证实寡妇血清硒水平较低这一发现。
