Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea.
Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Republic of Korea.
Obes Res Clin Pract. 2017 Sep-Oct;11(5 Suppl 1):133-143. doi: 10.1016/j.orcp.2016.12.007. Epub 2017 Jan 7.
We investigated the association of adipose tissue volume and metabolic activity with cardiometabolic risk factors.
232 healthy subjects (43.23±4.09y) having F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) results were included. Clinical information, anthropometry and laboratory results were obtained. Volume and metabolic activity of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was obtained from FDG PET/CT. Metabolic activity was presented as mean standardised uptake value (SUV). Adipose tissue parameters were compared with clinical and biochemical factors. Independent factors affecting adipose tissue volume were assessed.
Both SAT and VAT volume showed strong positive correlation with most of cardiometabolic risk factors. Among them, lipid profiles, insulin and C-reactive protein (CRP) had more significant relationship with SUV of SAT than that of VAT. On the contrary, glucose, glycated hemoglobin, and degree of fatty liver showed more significant correlation with SUV of VAT. BMI, age, sex and CRP were independent predictors of SAT volume. BMI, age, triglyceride, CRP and fatty liver were independent variables predicting VAT volume. Adding SUV of adipose tissue improved the model performance.
This study demonstrated that metabolic activities of SAT and VAT were differently correlated with risk factors, suggesting different biologic mechanism for obesity.
我们研究了脂肪组织体积和代谢活性与心血管代谢危险因素的关系。
共纳入 232 名健康受试者（43.23±4.09 岁），他们均接受 F-氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）检查。获取临床信息、人体测量学和实验室结果。通过 FDG PET/CT 获得皮下脂肪组织（SAT）和内脏脂肪组织（VAT）的体积和代谢活性。代谢活性表示为平均标准化摄取值（SUV）。比较脂肪组织参数与临床和生化因素。评估影响脂肪组织体积的独立因素。
SAT 和 VAT 体积均与大多数心血管代谢危险因素呈强正相关。其中，脂谱、胰岛素和 C 反应蛋白（CRP）与 SAT 的 SUV 比 VAT 的 SUV 有更显著的关系。相反，葡萄糖、糖化血红蛋白和脂肪肝程度与 VAT 的 SUV 有更显著的相关性。BMI、年龄、性别和 CRP 是 SAT 体积的独立预测因素。BMI、年龄、甘油三酯、CRP 和脂肪肝是预测 VAT 体积的独立变量。添加脂肪组织的 SUV 可提高模型性能。
本研究表明，SAT 和 VAT 的代谢活性与危险因素的相关性不同，提示肥胖具有不同的生物学机制。
