Brief Funct Genomics. 2017 Jul 1;16(4):217-227. doi: 10.1093/bfgp/elw040.
The genome of a pathogenic organism possesses a specific order of nucleotides that contains not only information about the synthesis and expression of proteomes, which are required for its growth and survival, but also about its evolution. Inhibition of any particular protein, which is required for the survival of that pathogenic organism, can be used as a potential therapeutic target for the development of effective drugs to treat its infections. In this review, the genomics, proteomics and evolution of dengue virus have been discussed, which will be helpful in better understanding of its origin, growth, survival and evolution, and may contribute toward development of new efficient anti-dengue drugs.
病原体的基因组具有特定的核苷酸顺序，不仅包含了合成和表达其生长和存活所必需的蛋白质组的信息，还包含了其进化的信息。抑制任何特定的蛋白质，对于该病原体的生存都是必需的，因此可以作为开发有效药物治疗其感染的潜在治疗靶点。在这篇综述中，讨论了登革热病毒的基因组学、蛋白质组学和进化，这将有助于更好地理解其起源、生长、存活和进化，并可能有助于开发新的有效的抗登革热药物。
