Dal Tio R, Di Vito F, Grasso F
G Ital Dermatol Venereol. 1989 Mar;124(3):77-83.
The Authors report a case of multiple brown slate macules localized on the lips and on the oral mucosa, occurred to a 66 year-old woman during cancer polychemotherapy with cis-diamminedichloroplatinum and Cyclophosphamide due to an ovary's serous cystadenocarcinoma with peritoneal metastasis. The histological test taken on a lip's lesion, fully excised, points out main focal hyperpigmentation of basal epidermal layer and numerous melanophages in the papillary dermis. The Authors, after a comparison among the information obtained from the literature, exclude any possible secondary reaction due to chemotherapy or any paraneoplastic syndrome. What they emphasize is the great similarity between the clinical and histological pictures noticed in this case and the ones described in the Laugier-Hunziker's syndrome. The particular association observed in this case is noteworthy but, nowadays following the existing knowledges, no relation of cause and effect between polychemotherapy, cancer and Laugier-Hunziker's disease can be advanced.
作者报告了一例66岁女性病例，该患者因卵巢浆液性囊腺癌伴腹膜转移，在接受顺二氯二氨铂和环磷酰胺联合化疗期间，嘴唇和口腔黏膜出现多处棕色石板样斑疹。对一处完全切除的唇部病变进行组织学检查，结果显示基底表皮层主要为局灶性色素沉着，乳头真皮层有大量噬黑素细胞。作者在对文献资料进行比较后，排除了化疗引起的任何可能的继发反应或任何副肿瘤综合征。他们强调，该病例中观察到的临床和组织学表现与劳吉尔-洪齐克尔综合征中描述的表现极为相似。该病例中观察到的特殊关联值得注意，但就目前现有的知识而言，无法推断联合化疗、癌症与劳吉尔-洪齐克尔病之间存在因果关系。
