一种用于活细胞中铁的高选择性荧光探针：基于应激诱导细胞的模型研究。
A highly selective fluorescent probe for Fe in living cells: a stress induced cell based model study.
作者信息
Sharma Neetu, Reja Shahi Imam, Gupta Neha, Bhalla Vandana, Kaur Davinder, Arora Saroj, Kumar Manoj
机构信息
Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India.
Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
出版信息
Org Biomol Chem. 2017 Jan 25;15(4):1006-1012. doi: 10.1039/c6ob02209j.
A rhodamine-phenanthroline dyad based fluorescent probe 4 has been designed and synthesized which selectively monitors Fe ions among the various metal ions tested. Furthermore, probe 4 has been explored for monitoring of dynamic changes in the Fe ion level under aggressive Fenton reaction conditions using a cell based model study. More significantly, probe 4 has also been utilized for real time imaging of endogenous Fe ions in living C6 cell lines, the results of which demonstrated that probe 4 acts as an efficient fluorescent tool for Fe ion detection in biological systems.
设计并合成了一种基于罗丹明-菲咯啉二元体系的荧光探针4，该探针在测试的各种金属离子中能选择性地监测铁离子。此外，利用基于细胞的模型研究，对探针4在剧烈芬顿反应条件下监测铁离子水平的动态变化进行了探索。更重要的是，探针4还被用于活C6细胞系内源性铁离子的实时成像，结果表明探针4是生物系统中铁离子检测的一种有效荧光工具。
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