Sharma Neetu, Reja Shahi Imam, Gupta Neha, Bhalla Vandana, Kaur Davinder, Arora Saroj, Kumar Manoj
Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India.
Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
Org Biomol Chem. 2017 Jan 25;15(4):1006-1012. doi: 10.1039/c6ob02209j.
A rhodamine-phenanthroline dyad based fluorescent probe 4 has been designed and synthesized which selectively monitors Fe ions among the various metal ions tested. Furthermore, probe 4 has been explored for monitoring of dynamic changes in the Fe ion level under aggressive Fenton reaction conditions using a cell based model study. More significantly, probe 4 has also been utilized for real time imaging of endogenous Fe ions in living C6 cell lines, the results of which demonstrated that probe 4 acts as an efficient fluorescent tool for Fe ion detection in biological systems.
设计并合成了一种基于罗丹明-菲咯啉二元体系的荧光探针4，该探针在测试的各种金属离子中能选择性地监测铁离子。此外，利用基于细胞的模型研究，对探针4在剧烈芬顿反应条件下监测铁离子水平的动态变化进行了探索。更重要的是，探针4还被用于活C6细胞系内源性铁离子的实时成像，结果表明探针4是生物系统中铁离子检测的一种有效荧光工具。
