Liang Li, Peng Shuwen, Yuan Zhenwei, Wei Chen, He Yuanyuan, Zheng Jinrong, Gu Yueqing, Chen Haiyan
Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University 24 Tongjia Lane, Gulou District Nanjing 210009 China
RSC Adv. 2018 Feb 6;8(11):6013-6026. doi: 10.1039/c7ra12796k. eCollection 2018 Feb 2.
Active targeting of tumor receptors is a significant approach for cancer diagnosis. Additionally, development of photothermal agents for photothermal therapy (PTT) has attracted great interest in the field of nanomedicine. In the present study, copper sulfide (CuS) nanoparticles capped with bovine serum albumin (BSA), named CuS@BSA, was synthesized by a convenient method. Then, the near-infrared (NIR) fluorescence probe MBA and the tumor-targeting ligand cyclic RGD were further conjugated on the surface of CuS@BSA, and the obtained nanocomposite was named CuS@BSA-MBA-cRGD. The morphology, optical properties, biotoxicity, tumor-targeting capability and and tumor inhibition effect were all characterized comprehensively. This nanocomplex demonstrated enhanced photothermal effects and positive tumor targeting. Thus, the nanocomposite CuS@BSA-MBA-cRGD can used as a promising tumor-targeting PTT agent for simultaneous cancer imaging and photothermal treatment.
肿瘤受体的主动靶向是癌症诊断的一种重要方法。此外，用于光热疗法（PTT）的光热剂的开发在纳米医学领域引起了极大的兴趣。在本研究中，通过一种简便的方法合成了用牛血清白蛋白（BSA）包覆的硫化铜（CuS）纳米颗粒，命名为CuS@BSA。然后，将近红外（NIR）荧光探针MBA和肿瘤靶向配体环RGD进一步共轭到CuS@BSA表面，所得纳米复合材料命名为CuS@BSA-MBA-cRGD。对其形态、光学性质、生物毒性、肿瘤靶向能力和肿瘤抑制效果进行了全面表征。这种纳米复合物表现出增强的光热效应和阳性肿瘤靶向性。因此，纳米复合材料CuS@BSA-MBA-cRGD可作为一种有前景的肿瘤靶向PTT剂，用于同时进行癌症成像和光热治疗。
