Tarnowski M, Malinowski D, Safranow K, Dziedziejko V, Pawlik A
Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
J Perinatol. 2017 Apr;37(4):345-348. doi: 10.1038/jp.2016.249. Epub 2017 Jan 12.
Gestational diabetes mellitus (GDM) is carbohydrate intolerance occurring in pregnant women. CDC123/CAMK1D and CDKN2A/2B are associated with increased risk of type 2 diabetes and may affect pancreatic beta cell function. The aim of this study was to examine the association between CDKN2A/2B rs10811661 and CDC123/CAMK1D rs12779790 gene polymorphisms and GDM.
This study included 411 pregnant women. The diagnosis of GDM was based on the International Association of Diabetes and Pregnancy Study Groups criteria. According to the results of their oral glucose tolerance test, the women were divided into two groups: 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance.
There were no statistically significant differences in the distribution of CDC123/CAMK1D rs12779790 genotypes and alleles between women with GDM and healthy pregnant women. However, there was a statistically significant association between the C allele of CDKN2A/2B rs10811661 polymorphism and reduced risk of GDM (C vs T, OR 0.53, 95% CI 0.36 to 0.79, P=0.0014). In the multivariate logistic regression analysis, older age and higher body mass index before pregnancy were independent significant predictors of a higher risk of GDM, while higher number of C alleles (CDKN2A/2B rs10811661) was a protective factor against GDM.
The results of this study suggest an association between CDKN2A/2B gene rs10811661 polymorphism and GDM.
妊娠期糖尿病（GDM）是孕妇出现的碳水化合物不耐受情况。CDC123/CAMK1D和CDKN2A/2B与2型糖尿病风险增加相关，且可能影响胰腺β细胞功能。本研究旨在探讨CDKN2A/2B rs10811661和CDC123/CAMK1D rs12779790基因多态性与GDM之间的关联。
本研究纳入411名孕妇。GDM的诊断基于国际糖尿病与妊娠研究组的标准。根据口服葡萄糖耐量试验结果，将这些女性分为两组：204名患有GDM的孕妇和207名糖耐量正常的孕妇。
患有GDM的女性与健康孕妇在CDC123/CAMK1D rs12779790基因型和等位基因的分布上无统计学显著差异。然而，CDKN2A/2B rs10811661多态性的C等位基因与GDM风险降低之间存在统计学显著关联（C与T相比，OR 0.53，95%CI 0.36至0.79，P = 0.0014）。在多因素逻辑回归分析中，年龄较大和孕前体重指数较高是GDM风险较高的独立显著预测因素，而C等位基因数量较多（CDKN2A/2B rs10811661）是预防GDM的保护因素。
本研究结果提示CDKN2A/2B基因rs10811661多态性与GDM之间存在关联。
