协同镍/铝催化对磺酰芳基的对选择性烷基化。
para-Selective Alkylation of Sulfonylarenes by Cooperative Nickel/Aluminum Catalysis.
机构信息
Department of Material Chemistry, Graduate School of Engineering, Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
出版信息
Org Lett. 2017 Feb 3;19(3):584-587. doi: 10.1021/acs.orglett.6b03741. Epub 2017 Jan 12.
PMID:28080066
Abstract
A method for the para-selective alkylation of a variety of arenesulfonamides and aromatic sulfones with 1-alkenes by cooperative nickel/aluminum catalysis has been developed. Taking advantage of the sulfornyl functionality serving as a removable ortho-directing group, the reaction can be applied to facile access to 1,3-dialkyl-substitued benzenes.
摘要
一种通过协同镍/铝催化，对各种芳基磺酰胺和芳基砜进行 para-选择性烷基化的方法已经被开发出来。利用亚磺酰基作为可去除的邻位导向基团的功能，该反应可用于轻松地获得 1,3-二烷基取代的苯。
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