• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

HIV与性腺功能减退:对抗逆转录病毒疗法有效的中青年男性面临的新挑战。

HIV and hypogonadism: a new challenge for young-aged and middle-aged men on effective antiretroviral therapy.

作者信息

Lachâtre Marie, Pasquet Armelle, Ajana Faïza, Soudan Benoit, Lion Georges, Bocket Laurence, Cornavin Pauline, Senneville Eric, Boufassa Faroudy, Chéret Antoine

机构信息

aDepartment of Infectious Diseases, Bichat-Claude-Bernard Hospital, AP-HPbParis Diderot University, Sorbonne Paris Cité, PariscDepartment of Infectious Diseases, Tourcoing Hospital, TourcoingdLaboratory of Biochemistry, Lille Hospital, LilleeDepartment of Nuclear Medicine, Lille Hospital, LillefLaboratory of Virology, Lille Hospital, LillegParis-Saclay University, Paris-Sud University, UVSQ, CESP U1018, INSERMhDepartment of Internal Medicine, Bicêtre Hospital, AP-HPiEA 7327 Paris Descartes University, Paris, France.

出版信息

AIDS. 2017 Jan 28;31(3):451-453. doi: 10.1097/QAD.0000000000001348.

DOI:10.1097/QAD.0000000000001348
PMID:28081039
Abstract

Male hypogonadism is poorly defined in people living with HIV. Using a reliable free-testosterone assay, we examined the prevalence and risk factors of male hypogonadism among people living with HIV on effective antiretroviral therapy. Male hypogonadism was found in 12.4% of patients, twice the rate reported in the general population of the same age. Two risk thresholds, namely 5 years of antiretroviral therapy and 19% total body fat, may help to identify patients at risk.

摘要

男性性腺功能减退在HIV感染者中定义不明确。我们使用可靠的游离睾酮检测方法,研究了接受有效抗逆转录病毒治疗的HIV感染者中男性性腺功能减退的患病率和危险因素。在12.4%的患者中发现了男性性腺功能减退,这一比例是同年龄普通人群报告率的两倍。两个风险阈值,即5年的抗逆转录病毒治疗和19%的体脂率,可能有助于识别有风险的患者。

相似文献

1
HIV and hypogonadism: a new challenge for young-aged and middle-aged men on effective antiretroviral therapy.HIV与性腺功能减退:对抗逆转录病毒疗法有效的中青年男性面临的新挑战。
AIDS. 2017 Jan 28;31(3):451-453. doi: 10.1097/QAD.0000000000001348.
2
The prevalence of low serum free testosterone and the short-term effect of anti-retroviral therapy in male Japanese treatment-naïve HIV patients.日本初治男性HIV患者低血清游离睾酮的患病率及抗逆转录病毒治疗的短期效果
J Infect Chemother. 2019 Apr;25(4):318-321. doi: 10.1016/j.jiac.2018.09.007. Epub 2018 Oct 4.
3
Prevalence of testosterone deficiency in HIV-infected men under antiretroviral therapy.接受抗逆转录病毒治疗的HIV感染男性中睾酮缺乏的患病率。
BMC Infect Dis. 2016 Nov 3;16(1):628. doi: 10.1186/s12879-016-1892-5.
4
Hypogonadism: a neglected comorbidity in young and middle-aged HIV-positive men on effective combination antiretroviral therapy.性腺功能减退症:接受有效抗逆转录病毒疗法的中青年 HIV 阳性男性中被忽视的合并症。
AIDS. 2022 Jul 1;36(8):1061-1071. doi: 10.1097/QAD.0000000000003176. Epub 2022 Feb 1.
5
Hypogonadism in the HIV-infected man.感染人类免疫缺陷病毒的男性性腺功能减退
Endocrinol Metab Clin North Am. 2014 Sep;43(3):709-30. doi: 10.1016/j.ecl.2014.06.005.
6
The determination of total testosterone and free testosterone (RIA) are not applicable to the evaluation of gonadal function in HIV-infected males.测定总睾酮和游离睾酮(RIA)不适用于评估 HIV 感染男性的性腺功能。
J Sex Med. 2010 Aug;7(8):2873-83. doi: 10.1111/j.1743-6109.2010.01886.x. Epub 2010 Jul 7.
7
Hypogonadism among HIV-positive men who have sex with men in Taiwan: Prevalence and associated factors.台湾男男性行为者中 HIV 阳性人群的性腺功能减退症:患病率及相关因素。
J Microbiol Immunol Infect. 2024 Oct;57(5):739-748. doi: 10.1016/j.jmii.2024.05.006. Epub 2024 May 24.
8
Prevalence of hypogonadism among men with weight loss related to human immunodeficiency virus infection who were receiving highly active antiretroviral therapy.接受高效抗逆转录病毒治疗的与人类免疫缺陷病毒感染相关体重减轻男性的性腺功能减退患病率。
Clin Infect Dis. 2000 Nov;31(5):1240-4. doi: 10.1086/317457. Epub 2000 Nov 2.
9
Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy.在感染HIV-1的男性中,性腺功能减退很常见,且在抗逆转录病毒治疗期间不会缓解。
Antivir Ther. 2007;12(2):261-5.
10
Prevalence of and Risk Factors for Low Free Testosterone Levels in Japanese Men with Well-controlled Human Immunodeficiency Virus Infection.日本 HIV 感染控制良好的男性中游离睾酮水平低的患病率和危险因素。
Curr HIV Res. 2020;18(5):381-386. doi: 10.2174/1570162X18666200720000344.

引用本文的文献

1
Prevalence of Hypogonadism and Associated Risk Factors among Newly Diagnosed ART Naïve HIV-Infected Males in Mwanza, Tanzania.坦桑尼亚姆万扎地区新诊断出的未接受过抗逆转录病毒治疗的HIV感染男性性腺功能减退症患病率及相关危险因素
Int J Endocrinol. 2024 Mar 5;2024:9679935. doi: 10.1155/2024/9679935. eCollection 2024.
2
Sexual Dysfunctions Among People Living With HIV With Long-Term Treatment With Antiretroviral Therapy.接受抗逆转录病毒疗法长期治疗的艾滋病毒感染者的性功能障碍
Sex Med. 2022 Oct;10(5):100542. doi: 10.1016/j.esxm.2022.100542. Epub 2022 Jul 21.
3
Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice.
年龄相关的神经内分泌、认知和行为合并症是由雄性小鼠中的 HIV-1 Tat 表达所促进的。
Aging (Albany NY). 2022 Jul 12;14(13):5345-5365. doi: 10.18632/aging.204166.
4
Allopregnanolone and neuroHIV: Potential benefits of neuroendocrine modulation in the era of antiretroviral therapy.别孕烯醇酮与神经艾滋病:抗逆转录病毒治疗时代神经内分泌调节的潜在益处。
J Neuroendocrinol. 2022 Feb;34(2):e13047. doi: 10.1111/jne.13047. Epub 2021 Oct 14.
5
Redefining therapeutic success in HIV patients: an expert view.重新定义 HIV 患者的治疗成功:专家观点。
J Antimicrob Chemother. 2021 Sep 15;76(10):2501-2518. doi: 10.1093/jac/dkab168.
6
The importance of SHBG and calculated free testosterone for the diagnosis of symptomatic hypogonadism in HIV-infected men: a single-centre real-life experience.SHBG 和计算游离睾酮在诊断 HIV 感染男性有症状性腺功能减退症中的重要性:单中心真实世界经验。
Infection. 2021 Apr;49(2):295-303. doi: 10.1007/s15010-020-01558-6. Epub 2020 Dec 8.
7
Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects.孕烷类固醇生成受HIV-1反式激活蛋白(Tat)和吗啡影响:生理性别孕烷醇酮可预防神经毒性和精神运动效应。
Neurobiol Stress. 2020 Jan 29;12:100211. doi: 10.1016/j.ynstr.2020.100211. eCollection 2020 May.
8
Diagnosis, prevention, and treatment of bone fragility in people living with HIV: a position statement from the Swiss Association against Osteoporosis.诊断、预防和治疗 HIV 感染者的骨脆弱症:瑞士抗骨质疏松协会立场声明。
Osteoporos Int. 2019 May;30(5):1125-1135. doi: 10.1007/s00198-018-4794-0. Epub 2019 Jan 2.
9
Antiretroviral Therapy and Alcohol Interactions: X-raying Testicular and Seminal Parameters Under the HAART Era.抗逆转录病毒疗法与酒精的相互作用:透视高效抗逆转录病毒治疗时代的睾丸和精液参数
Eur J Drug Metab Pharmacokinet. 2018 Apr;43(2):121-135. doi: 10.1007/s13318-017-0438-6.
10
Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy.抗PD-L1抗体BMS-936559在接受抗逆转录病毒抑制治疗的HIV-1感染参与者中的临床试验。
J Infect Dis. 2017 Jun 1;215(11):1725-1733. doi: 10.1093/infdis/jix191.