Watson Penny
Department of Veterinary Medicine, Queen's Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
Vet Clin North Am Small Anim Pract. 2017 May;47(3):665-682. doi: 10.1016/j.cvsm.2016.11.013. Epub 2017 Jan 9.
Canine hepatopathies, both congenital and acquired, arise from an interaction between genes and environment. Many show increased breed prevalences. This article reviews the current understanding on breed predispositions for congenital portosystemic shunts; microvascular dysplasia and portal vein hypoplasia; ductal plate abnormalities (congenital hepatic fibrosis and Caroli disease); chronic hepatitis (both copper associated and idiopathic); vacuolar hepatopathies; and gallbladder mucocele. Although all these diseases can occur in many breeds and crossbreeds, understanding breed predispositions helps recognition and will guide future research to improve understanding of causes and treatments.
犬类肝病，包括先天性和后天性的，是由基因与环境之间的相互作用引起的。许多肝病在特定品种中具有较高的发病率。本文综述了目前对先天性门体分流、微血管发育异常和门静脉发育不全、导管板异常（先天性肝纤维化和卡罗利病）、慢性肝炎（铜相关和特发性）、空泡性肝病以及胆囊黏液囊肿等疾病品种易感性的认识。尽管所有这些疾病都可能发生在许多品种和杂交品种中，但了解品种易感性有助于疾病的识别，并将指导未来的研究，以增进对病因和治疗方法的理解。
