Allerton F, Swinbourne F, Barker L, Black V, Kathrani A, Tivers M, Henriques T, Kisielewicz C, Dunning M, Kent A
Willows Veterinary Centre and Referral Service, Highlands Road, Shirley, Solihull, B90 4NH, The United Kingdom.
Bristol Veterinary School, University of Bristol, Langford, Bristol, BS40 5DU, The United Kingdom.
J Vet Intern Med. 2018 Sep;32(5):1618-1628. doi: 10.1111/jvim.15249. Epub 2018 Aug 5.
Gall bladder mucoceles (GBM) are a leading cause of biliary disease in dogs with several breeds, including the Shetland Sheepdog, American Cocker Spaniel, Chihuahua, Pomeranian, and Miniature Schnauzer apparently predisposed.
To determine risk factors, clinical features, and response to treatment of GBM in Border terriers (BT).
Medical records of 99 dogs (including 51 BT) with an ultrasonographic (±histopathologic) diagnosis of GBM from three referral centers in the United Kingdom were collected. A control group of 87 similar-aged BT with no ultrasonographic evidence of gall bladder disease was selected for comparison.
Retrospective case-control study. Odds ratios were calculated to establish breed predisposition. Signalment, presence of endocrine disease, clinicopathologic results, and outcome were compared between the BT, other breeds, and control BTs.
The odds of identifying a GBM in a BT in this hospital population was 85 times that of all other breeds (95% confidence interval 56.9-126.8). BT had similar clinical signs and clinicopathologic changes to other breeds with GBM. There was no evidence that endocrinopathies were associated with GBM in BT.
A robust breed predisposition to GBM is established for the BT.
胆囊黏液囊肿（GBM）是犬类胆道疾病的主要病因，包括设得兰牧羊犬、美国可卡犬、吉娃娃犬、博美犬和迷你雪纳瑞犬等多个品种显然易患此病。
确定边境梗犬（BT）患GBM的风险因素、临床特征及对治疗的反应。
收集了来自英国三个转诊中心的99只经超声检查（±组织病理学）诊断为GBM的犬（包括51只BT）的病历。选取87只年龄相仿、无胆囊疾病超声证据的BT作为对照组进行比较。
回顾性病例对照研究。计算比值比以确定品种易感性。比较了BT、其他品种和对照BT的信号、内分泌疾病的存在情况、临床病理结果及转归。
在该医院群体中，BT患GBM的几率是所有其他品种的85倍（95%置信区间56.9 - 126.8）。BT与其他患GBM的品种有相似的临床症状和临床病理变化。没有证据表明内分泌疾病与BT的GBM有关。
确定了BT对GBM有很强的品种易感性。
