Hidalgo-Santamaria María, Fernandez-Montero Alejandro, Martinez-Gonzalez Miguel A, Moreno-Galarraga Laura, Sanchez-Villegas Almudena, Barrio-Lopez María T, Bes-Rastrollo Maira
Department of Internal Medicine, University of Navarra Clinic, Pamplona, Navarra, Spain.
Department of Occupational Medicine, University of Navarra Clinic, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra, Pamplona, Navarra, Spain.
Am J Prev Med. 2017 Apr;52(4):e95-e101. doi: 10.1016/j.amepre.2016.11.021. Epub 2017 Jan 9.
Emerging evidence suggests that vigorous physical activity may be associated with higher cardioprotective benefits than moderate physical activity. This study aimed to assess the long-term relationship between the intensity of leisure time physical activity (LTPA) and the risk of developing metabolic syndrome (MS) in a prospective cohort study.
The Seguimiento Universidad de Navarra (SUN) Project comprises Spanish university graduates. Participants (n=10,145) initially free of MS were followed for a minimum of 6 years (2008-2014). Analysis was conducted in 2015. Physical activity was assessed though a validated questionnaire. The intensity of each physical activity was measured in METs. The intensity of LTPA was estimated by the ratio between total METs/week and total hours of LTPA/week, obtaining the mean METs/hour of LTPA. MS was defined according to the harmonizing definition. The association between the intensity of LTPA (METs/hour) and MS was assessed with logistic regression models adjusting for potential confounders.
Among 10,145 participants initially free of any MS criteria, 412 new MS cases were observed. Vigorous LTPA was associated with a 37% relatively lower risk (AOR=0.63, 95% CI=0.44, 0.89) compared with light LTPA. For a given total energy expenditure, independent of the time spent on it, participants who performed vigorous LTPA exhibited a higher reduction in the risk of MS than those who performed light to moderate LTPA.
Vigorous LTPA was significantly associated with lower risk of developing MS after a 6-year follow-up period.
新出现的证据表明，剧烈体育活动可能比中等强度体育活动具有更高的心脏保护益处。本研究旨在通过一项前瞻性队列研究评估休闲时间体育活动（LTPA）强度与发生代谢综合征（MS）风险之间的长期关系。
纳瓦拉大学随访项目（SUN项目）包括西班牙大学毕业生。对最初无MS的参与者（n = 10145）进行了至少6年（2008 - 2014年）的随访。2015年进行了分析。通过一份经过验证的问卷评估体育活动情况。每项体育活动的强度以代谢当量（METs）衡量。LTPA强度通过每周总METs与每周LTPA总小时数的比值估算得出，从而得到LTPA的平均METs/小时。MS根据统一的定义确定。使用逻辑回归模型评估LTPA强度（METs/小时）与MS之间的关联，并对潜在混杂因素进行调整。
在10145名最初不符合任何MS标准的参与者中，观察到412例新的MS病例。与轻度LTPA相比，剧烈LTPA的相对风险降低37%（比值比[AOR]=0.63，95%置信区间[CI]=0.44，0.89）。对于给定的总能量消耗，无论花费时间多少，进行剧烈LTPA的参与者比进行轻度至中度LTPA的参与者发生MS的风险降低幅度更大。
经过6年随访期后，剧烈LTPA与发生MS的较低风险显著相关。
