Anand David Alexander Victor, Arulmoli Radhakrishnan, Parasuraman Subramani
Unit of Anatomy, Faculty of Medicine, AIMST University, Bedong, Malaysia.
Unit of Pharmacology, Faculty of Pharmacy, AIMST University, Bedong 08100, Malaysia.
Pharmacogn Rev. 2016 Jul-Dec;10(20):84-89. doi: 10.4103/0973-7847.194044.
Antioxidants are substances that may protect cells from the damage caused by unstable molecules such as free radicals. Flavonoids are phenolic substances widely found in fruits and vegetables. The previous studies showed that the ingestion of flavonoids reduces the risk of cardiovascular diseases, metabolic disorders, and certain types of cancer. These effects are due to the physiological activity of flavonoids in the reduction of oxidative stress, inhibiting low-density lipoproteins oxidation and platelet aggregation, and acting as vasodilators in blood vessels. Free radicals are constantly generated resulting in extensive damage to tissues leading to various disease conditions such as cancer, Alzheimer's, renal diseases, cardiac abnormalities, etc., Medicinal plants with antioxidant properties play a vital functions in exhibiting beneficial effects and employed as an alternative source of medicine to mitigate the disease associated with oxidative stress. Flavonoids have existed over one billion years and possess wide spectrum of biological activities that might be able to influence processes which are dysregulated in a disease. Quercetin, a plant pigment is a potent antioxidant flavonoid and more specifically a flavonol, found mostly in onions, grapes, berries, cherries, broccoli, and citrus fruits. It is a versatile antioxidant known to possess protective abilities against tissue injury induced by various drug toxicities.
抗氧化剂是一类可以保护细胞免受自由基等不稳定分子造成损伤的物质。黄酮类化合物是广泛存在于水果和蔬菜中的酚类物质。先前的研究表明，摄入黄酮类化合物可降低心血管疾病、代谢紊乱和某些类型癌症的风险。这些作用归因于黄酮类化合物在减轻氧化应激、抑制低密度脂蛋白氧化和血小板聚集以及作为血管舒张剂方面的生理活性。自由基不断产生，会对组织造成广泛损伤，导致各种疾病，如癌症、阿尔茨海默病、肾脏疾病、心脏异常等。具有抗氧化特性的药用植物在发挥有益作用方面起着至关重要的作用，并被用作替代药物来源，以减轻与氧化应激相关的疾病。黄酮类化合物已经存在了超过十亿年，具有广泛的生物活性，可能能够影响疾病中失调的过程。槲皮素是一种植物色素，是一种有效的抗氧化黄酮类化合物，更具体地说是一种黄酮醇，主要存在于洋葱、葡萄、浆果、樱桃、西兰花和柑橘类水果中。它是一种多功能抗氧化剂，已知具有针对各种药物毒性引起的组织损伤的保护能力。
