Department of Biochemistry, Central University of Haryana, Mahendergarh 123031, India.
Molecules. 2022 Apr 13;27(8):2498. doi: 10.3390/molecules27082498.
Polyphenols are the known group of phytochemicals that essentially consists of phenolic rings. These are the plant product present in varied fruits and vegetables. These secondary metabolites perform a protective function in plants from environmental and biological stress. When consumed as a human diet these are also known to prevent various age-associated diseases. Polyphenols are known to possess antioxidant properties and protect against oxidative stress. The literature survey was carried out using databases such as PubMed, Science direct and Springer. The research articles from last 10-12 years were selected for this review based on its relevancy with the topic. The articles selected was mainly focused on quercetin and its health benefits. The present review highlights the main functions of a flavonoid, quercetin. Quercetin is among the widely occurring polyphenol, found abundantly in nature. It is commonly present in different plant products. Onion is known to have the highest quantity of quercetin. This plant compound is possessed antioxidant properties and is considered to have a protective function against aging. It is known to be present in both free and conjugated forms. Quercetin has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, and anti-viral properties. The molecule is lipophilic and can easily cross the BBB (Blood-Brain Barrier) and hence protects from neurodegenerative diseases. Various in vivo and in vitro studies have demonstrated the role of quercetin and here a detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out. Studies have proved that quercetin plays a crucial role in the prevention of age-related disorders. Quercetin is a potent antioxidant which is currently being used in various pharmaceuticals. Properties of quercetin can be further explored in various other disorders. Nanoformulations and liposomal formulations of quercetin can be made to treat other age associated diseases.
多酚是一类已知的植物化学物质，主要由酚环组成。这些是存在于各种水果和蔬菜中的植物产物。这些次生代谢物在植物中起到了保护作用，可以抵御环境和生物压力。当作为人类饮食的一部分被摄入时，它们也被认为可以预防各种与年龄相关的疾病。多酚具有抗氧化特性，可以防止氧化应激。文献调查是使用 PubMed、Science Direct 和 Springer 等数据库进行的。根据与主题的相关性，选择了过去 10-12 年的研究文章进行综述。选择的文章主要集中在槲皮素及其健康益处上。本综述强调了黄酮类化合物槲皮素的主要功能。槲皮素是广泛存在的多酚之一，在自然界中大量存在。它通常存在于不同的植物产品中。洋葱被认为含有最高量的槲皮素。这种植物化合物具有抗氧化特性，被认为对衰老具有保护作用。它既可以以游离形式存在，也可以以共轭形式存在。槲皮素有抗氧化、抗炎、抗增殖、抗癌、抗糖尿病和抗病毒的特性。该分子具有亲脂性，很容易穿过血脑屏障（BBB），因此可以预防神经退行性疾病。各种体内和体外研究都证明了槲皮素的作用，这里对槲皮素作为神经退行性疾病、糖尿病、癌症和炎症的治疗剂的作用进行了详细的综述。研究证明，槲皮素在预防与年龄相关的疾病方面起着至关重要的作用。槲皮素是一种有效的抗氧化剂，目前正在各种药物中使用。可以进一步探索槲皮素在其他各种疾病中的特性。可以制造槲皮素的纳米制剂和脂质体制剂来治疗其他与年龄相关的疾病。
