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澳大利亚青少年的腹腔镜可调节胃束带术:是否应该实施?

Laparoscopic Adjustable Gastric Banding in Australian Adolescents: Should It Be Done?

作者信息

Peña Alexia Sophie, Delko Tarik, Couper Richard, Sutton Kerri, Kritas Stamatiki, Omari Taher, Chisholm Jacob, Kow Lilian, Khurana Sanjeev

机构信息

Robinson Research Institute and Discipline of Paediatrics, The University of Adelaide, Adelaide, South Australia, Australia.

Endocrinology and Diabetes Department, Women's and Children's Hospital (WCH), North Adelaide, South Australia, Australia.

出版信息

Obes Surg. 2017 Jul;27(7):1667-1673. doi: 10.1007/s11695-017-2544-6.

Abstract

OBJECTIVE

There are very few studies on laparoscopic adjustable gastric banding (LAGB) in obese adolescents with follow up for more than 36 months, let alone good prospective data beyond 24 months in Australian adolescents. We aimed to evaluate medium term (>36 months) safety and efficacy of LAGB in adolescents with severe obesity.

METHODS

This is a prospective cohort study (March 2009-December 2015) in one tertiary referral hospital including obese adolescents (14-18 years) with a body mass index (BMI) >40 (or ≥35 with comorbidities) who consented to have LAGB. Exclusion criteria were syndromal causes of obesity, depression and oesophageal motility disorders. Main outcome measures include change in weight and BMI at 6, 12, 24, 36 and 48 months post LAGB; postoperative complications; and admissions.

RESULTS

Twenty-one adolescents (median [interquartile range (IQR)] 17.4 [16.5-17.7] years, 9 males, mean ± SD BMI 47.3 ± 8.4 kg/m) had a median follow up of 45.5 [32-50] months post LAGB. Follow up data were available for 16 adolescents. Weight and BMI improved significantly at all follow up times (all p < 0.01). The median maximum BMI loss was 10 [7.1-14.7] kg/m. There were four minor early complications. Seven bands were removed due to weight loss failure/regain (two had also obstructive symptoms).

CONCLUSIONS

We have shown in the longest prospective LAGB postoperative follow up study of Australian adolescents that LAGB improves BMI in the majority of adolescents without significant comorbidities. LAGB is still a reasonable option to be considered as a temporary procedure to manage severe obesity during adolescence.

摘要

目的

关于肥胖青少年腹腔镜可调节胃束带术(LAGB)且随访超过36个月的研究极少,更不用说澳大利亚青少年超过24个月的良好前瞻性数据了。我们旨在评估LAGB对重度肥胖青少年的中期(>36个月)安全性和有效性。

方法

这是一项在一家三级转诊医院进行的前瞻性队列研究(2009年3月至2015年12月),纳入了体重指数(BMI)>40(或伴有合并症时BMI≥35)且同意接受LAGB的肥胖青少年(14 - 18岁)。排除标准为肥胖的综合征病因、抑郁症和食管动力障碍。主要结局指标包括LAGB术后6、12、24、36和48个月时体重和BMI的变化;术后并发症;以及住院情况。

结果

21名青少年(中位年龄[四分位间距(IQR)]17.4[16.5 - 17.7]岁,9名男性,平均±标准差BMI为47.3±8.4kg/m²)在LAGB术后的中位随访时间为45.5[32 - 50]个月。16名青少年有随访数据。在所有随访时间点,体重和BMI均显著改善(所有p<0.01)。最大BMI损失的中位数为10[7.1 - 14.7]kg/m²。有4例轻微的早期并发症。7条束带因体重减轻失败/体重反弹而被移除(2例还伴有梗阻症状)。

结论

我们在澳大利亚青少年最长的LAGB术后前瞻性随访研究中表明,LAGB可使大多数无明显合并症的青少年BMI得到改善。LAGB仍是青春期管理重度肥胖的一种合理的临时手术选择。

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