Riestra Pia, Gebreab Samson Y, Xu Ruihua, Khan Rumana J, Quarels Rakale, Gibbons Gary, Davis Sharon K
Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Sleep Breath. 2017 Sep;21(3):751-757. doi: 10.1007/s11325-016-1451-8. Epub 2017 Jan 12.
Shorter telomere length and obstructive sleep apnea are associated with increased oxidative stress and chronic inflammation, which are both considered leading causes of age-related diseases. Different forms of sleep disordered breathing have been linked to telomere length although their relationship remains uncertain. The purpose of this study was to explore the associations between the risk of obstructive sleep apnea and telomere length in African Americans.
The analysis included 184 women and 122 men aged 30-55 years from the Morehouse School of Medicine Study. Relative TL (T/S ratio) was measured from peripheral blood leukocytes using quantitative real-time polymerase chain reaction. The Berlin questionnaire was used for OSA risk assessments. Multivariable linear regression models were used to examine the associations between OSA risk and LTL.
We observed that LTL varied by OSA risk in women (0.532 ± 0.006 vs. 0.569 ± 0.008) (p = 0.04). Multiple linear regression analysis confirmed that women at higher risk for OSA presented shorter LTL compared to those at lower risk, independent of age, income, education, obesity, smoking, alcohol consumption, and hypertension. These differences were not observed in men.
Our findings suggest that OSA risk may contribute to the acceleration of cellular aging processes through telomere shortening.
较短的端粒长度与阻塞性睡眠呼吸暂停与氧化应激增加和慢性炎症相关，这两者都被认为是与年龄相关疾病的主要原因。不同形式的睡眠呼吸障碍与端粒长度有关，尽管它们之间的关系仍不确定。本研究的目的是探讨非裔美国人阻塞性睡眠呼吸暂停风险与端粒长度之间的关联。
分析纳入了莫尔豪斯医学院研究中184名年龄在30 - 55岁之间的女性和122名男性。使用定量实时聚合酶链反应从外周血白细胞中测量相对端粒长度（T/S比值）。柏林问卷用于阻塞性睡眠呼吸暂停风险评估。多变量线性回归模型用于检验阻塞性睡眠呼吸暂停风险与端粒长度之间的关联。
我们观察到女性中端粒长度因阻塞性睡眠呼吸暂停风险而异（0.532 ± 0.006对0.569 ± 0.008）（p = 0.04）。多元线性回归分析证实，与低风险女性相比，阻塞性睡眠呼吸暂停高风险女性的端粒长度更短，不受年龄、收入、教育程度、肥胖、吸烟、饮酒和高血压的影响。在男性中未观察到这些差异。
我们的研究结果表明，阻塞性睡眠呼吸暂停风险可能通过端粒缩短导致细胞衰老过程加速。
