Roncon de Albuquerque R, Delgado L, Correia P, Torrinha J F, Serrão D, Braga A
Hospital de S. João, Oporto, Portugal.
J Cardiovasc Surg (Torino). 1989 Sep-Oct;30(5):821-5.
Auto-antibodies such as anti-elastin, anti-collagen, anti-nuclear and anti-arterial, circulating immune complexes, and cellular responses to collagen I and III are known to be present in Buerger's disease (EO). Deposits of IgG, C3 and C4 have also been found in the vascular lesions of endarteritis obliterans (EO) in young men. The purpose of this study was to correlate clinical evidence of vascular disease with the presence of the circulating immune complexes. Thirty-three patients suffering from Buerger's disease (EO), 20 patients suffering from atherosclerosis (AT) and 20 normal controls (Norm) were studied. All were male, heavy smokers, and age-matched. Five techniques were used: direct nephelometry, nephelometry with protamine, two polyethyleneglycol precipitation methods (PegIgG and PegC4), and an immuno-enzymatic C1q fixation test (C1qE). The results seem to confirm the presence of circulating immune complexes in peripheral arterial disease in young men who are heavy smokers, particularly those suffering from EO.
已知在血栓闭塞性脉管炎（EO）患者体内存在自身抗体，如抗弹性蛋白、抗胶原蛋白、抗核抗体和抗动脉抗体、循环免疫复合物以及对I型和III型胶原蛋白的细胞反应。在年轻男性闭塞性动脉内膜炎（EO）的血管病变中也发现了IgG、C3和C4的沉积。本研究的目的是将血管疾病的临床证据与循环免疫复合物的存在相关联。对33例血栓闭塞性脉管炎（EO）患者、20例动脉粥样硬化（AT）患者和20名正常对照者（Norm）进行了研究。所有受试者均为男性，重度吸烟者，且年龄匹配。采用了五种技术：直接比浊法、鱼精蛋白比浊法、两种聚乙二醇沉淀法（PegIgG和PegC4）以及免疫酶C1q固定试验（C1qE）。结果似乎证实，在重度吸烟的年轻男性外周动脉疾病患者中，尤其是血栓闭塞性脉管炎（EO）患者体内存在循环免疫复合物。
