Fernandes Queenie
Hamad Medical Corporation, P.O. Box 4572, Doha, Qatar.
Blood Rev. 2017 May;31(3):129-138. doi: 10.1016/j.blre.2016.11.003. Epub 2016 Nov 24.
MicroRNAs (miRNAs) are endogenous short non-coding RNAs found to play key roles in the pathogenesis of leukemia. Apart from being traditionally identified as modulators of oncogenes, the potential roles of miRNAs seems to be growing with novel and recent findings among different subtypes of hematological malignancies. Leukemia is one of the earliest malignancies to be linked to abnormal expression of miRNAs. However, a clear understanding of the involvement of miRNAs in intricate mechanisms of leukemogenesis is still a necessity. This review summarizes the multiple roles of miRNAs in the pathogenesis of leukemia and highlights major research findings contributing to these aspects.
微小RNA（miRNA）是一类内源性短链非编码RNA，已发现其在白血病发病机制中发挥关键作用。除了传统上被认为是癌基因的调节因子外，随着血液系统恶性肿瘤不同亚型的新发现和最新研究成果，miRNA的潜在作用似乎在不断增加。白血病是最早与miRNA异常表达相关的恶性肿瘤之一。然而，仍有必要深入了解miRNA在白血病发生复杂机制中的作用。本综述总结了miRNA在白血病发病机制中的多种作用，并重点介绍了在这些方面的主要研究成果。
