Ravari Ali, Mirzaei Tayebeh, Kennedy Derek, Kazemi Arababadi Mohammad
Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Dept. of Medical Surgical Nursing, Faculty of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Dept. of Medical Surgical Nursing, Faculty of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Life Sci. 2017 Feb 15;171:16-20. doi: 10.1016/j.lfs.2017.01.003. Epub 2017 Jan 11.
Aging is associated with a range of chronic low-grade inflammation (Chronoinflammaging) which may play a significant role in some chronic inflammatory based diseases, such as Alzheimer disease (AD). However, the events which lead to the induction of chronoinflammaging in AD are yet to be clarified. It has been proposed that the recognition of endogenous ligands by pathogen recognition receptors (PRRs) may be involved in the induction of chronoinflammaging. Toll like receptors (TLRs) are a family of PRRs which recognize endogenous damage associated molecular patterns (DAMPs) and subsequently induce inflammation. Therefore, TLRs are worthy of investigation to elucidate their roles in chronoinflammaging associated AD. This review article explores the main roles played by TLR2 in the pathogenesis of chronoinflammaging in patients suffering from AD.
衰老与一系列慢性低度炎症（慢性炎症衰老）相关，这可能在某些基于慢性炎症的疾病中起重要作用，如阿尔茨海默病（AD）。然而，导致AD中慢性炎症衰老诱导的事件尚待阐明。有人提出，病原体识别受体（PRRs）对内源性配体的识别可能参与慢性炎症衰老的诱导。Toll样受体（TLRs）是一类PRRs，可识别内源性损伤相关分子模式（DAMPs）并随后诱导炎症。因此，TLRs在阐明其在与慢性炎症衰老相关的AD中的作用方面值得研究。这篇综述文章探讨了TLR2在AD患者慢性炎症衰老发病机制中的主要作用。
