Cagel Maximiliano, Tesan Fiorella C, Bernabeu Ezequiel, Salgueiro Maria J, Zubillaga Marcela B, Moretton Marcela A, Chiappetta Diego A
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Tecnología Farmacéutica I, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Física, Buenos Aires, Argentina.
Eur J Pharm Biopharm. 2017 Apr;113:211-228. doi: 10.1016/j.ejpb.2016.12.019. Epub 2017 Jan 11.
During the past few decades, polymeric micelles have raised special attention as novel nano-sized drug delivery systems for optimizing the treatment and diagnosis of numerous diseases. These nanocarriers exhibit several in vitro and in vivo advantages as well as increased stability and solubility to hydrophobic drugs. An interesting approach for optimizing these properties and overcoming some of their disadvantages is the combination of two or more polymers in order to assemble polymeric mixed micelles. This review article gives an overview on the current state of the art of several mixed micellar formulations as nanocarriers for drugs and imaging probes, evaluating their ongoing status (preclinical or clinical stage), with special emphasis on type of copolymers, physicochemical properties, in vivo progress achieved so far and toxicity profiles. Besides, the present article presents relevant research outcomes about polymeric mixed micelles as better drug delivery systems, when compared to polymeric pristine micelles. The reported data clearly illustrates the promise of these nanovehicles reaching clinical stages in the near future.
在过去几十年里，聚合物胶束作为新型纳米级药物递送系统，在优化多种疾病的治疗和诊断方面引起了特别关注。这些纳米载体在体外和体内均表现出多种优势，同时对疏水性药物的稳定性和溶解性也有所提高。优化这些特性并克服其一些缺点的一种有趣方法是将两种或更多种聚合物组合，以组装聚合物混合胶束。这篇综述文章概述了几种混合胶束制剂作为药物和成像探针纳米载体的当前技术水平，评估了它们的进展情况（临床前或临床阶段），特别强调了共聚物类型、物理化学性质、迄今为止在体内取得的进展以及毒性概况。此外，与原始聚合物胶束相比，本文还介绍了有关聚合物混合胶束作为更好的药物递送系统的相关研究成果。报道的数据清楚地表明了这些纳米载体在不久的将来进入临床阶段的前景。
