Lacuey Nuria, Zonjy Bilal, Londono Luisa, Lhatoo Samden D
From the Epilepsy Center (N.L., B.Z., L.L., S.D.L.), UH Cleveland Medical Center, Cleveland, OH; Department of Neurology (N.L.), Vall d 'Hebron University Hospital; Department of Medicine (N.L.), Universitat Autonoma of Barcelona, Spain; and NINDS Center for SUDEP Research (CSR) (S.D.L.), Cleveland, OH.
Neurology. 2017 Feb 14;88(7):701-705. doi: 10.1212/WNL.0000000000003613. Epub 2017 Jan 13.
To identify limbic sites of respiratory control in the human brain, and by extension, the symptomatogenic zone for central apnea.
We used direct stimulation of anatomically, precisely placed stereotactic EEG electrodes to analyze breathing responses. We prospectively studied 3 patients who were explored with stereotactically implanted depth electrodes. The amygdala and hippocampus, as well as extralimbic sites (orbitofrontal, temporal tip, and temporal neocortex), were investigated.
Individual stimulation of the amygdala and hippocampal head consistently elicited central apnea in the expiratory phase, as did exquisitely focal hippocampal seizures.
These findings confirm that hippocampus and amygdala are limbic breathing control sites in humans, as well as the symptomatogenic zone for central apneic seizures.
确定人类大脑中呼吸控制的边缘系统部位，进而确定中枢性呼吸暂停的症状发生区。
我们使用直接刺激解剖学上精确放置的立体定向脑电图电极来分析呼吸反应。我们前瞻性地研究了3例接受立体定向植入深度电极探索的患者。对杏仁核、海马体以及边缘外部位（眶额叶、颞叶尖和颞叶新皮质）进行了研究。
单独刺激杏仁核和海马头部在呼气期持续引发中枢性呼吸暂停，精准的局灶性海马癫痫发作时也是如此。
这些发现证实，海马体和杏仁核是人类边缘系统呼吸控制部位，也是中枢性呼吸暂停发作的症状发生区。
