Rademaker M, Lowe D G, Munro D D
Department of Dermatology, St. Bartholomew's Hospital, London, England.
J Am Acad Dermatol. 1989 Oct;21(4 Pt 1):740-5. doi: 10.1016/s0190-9622(89)70248-6.
The clinical and histologic features of 26 cases of erythema induratum are reviewed. The characteristic cutaneous lesions on the legs of middle-aged women were violaceous, indurated nodules, 1 to 2 cm in diameter, which were painful, occasionally ulcerated, and could heal with scarring. The diagnosis was confirmed in all patients by a strongly positive Mantoux test result (1:10,000 dilution) and by clearing of lesions after antituberculosis therapy. The histologic features were varied but were predominantly those of a vasculitis with a paraseptal and lobular panniculitis. Although it was not possible to fulfill the required criteria for diagnosing tuberculosis in these lesions, we believe there is sufficient circumstantial evidence to support the hypothesis that erythema induratum is a true tuberculid.
回顾了26例硬结性红斑的临床和组织学特征。中年女性腿部特征性皮肤损害为紫红色硬结性结节，直径1至2厘米，有压痛，偶有溃疡，愈合后留瘢痕。所有患者结核菌素试验（1:10,000稀释度）结果均为强阳性，抗结核治疗后皮损消退，确诊为此病。组织学特征多样，但主要为伴有间隔旁和小叶性脂膜炎的血管炎。虽然这些损害中无法满足诊断结核的必要标准，但我们认为有足够的间接证据支持硬结性红斑是一种真正结核疹的假说。
