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饮酒与胃癌风险：一项荟萃分析。

Alcohol Consumption and Gastric Cancer Risk: A Meta-Analysis.

作者信息

Ma Ke, Baloch Zulqarnain, He Ting-Ting, Xia Xueshan

机构信息

Department of Pharmacology, Medical College of Qingdao University, Qingdao, Shandong, China (mainland).

Viral Gene Lab, College of Veterinary Medicine, South China Agriculture University, Guangzhou, Guangdong, China (mainland).

出版信息

Med Sci Monit. 2017 Jan 14;23:238-246. doi: 10.12659/msm.899423.

DOI:10.12659/msm.899423
PMID:28087989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5256369/
Abstract

BACKGROUND We sought to determine by meta-analysis the relationship between drinking alcohol and the risk of gastric cancer. MATERIAL AND METHODS A systematic Medline search was performed to identify all published reports of drinking alcohol and the associated risk of gastric cancer. Initially we retrieved 2,494 studies, but after applying inclusion and exclusion criteria, only ten studies were found to be eligible for our meta-analysis. RESULTS Our meta-analysis showed that alcohol consumption elevated the risk of gastric cancer with an odds ratio (OR) of 1.39 (95% CI 1.20-1.61). Additionally, subgroup analysis showed that only a nested case-control report from Sweden did not support this observation. Subgroup analysis of moderate drinking and heavy drinking also confirmed that drinking alcohol increased the risk of gastric cancer. Publication bias analysis (Begg's and Egger's tests) showed p values were more than 0.05, suggesting that the 10 articles included in our analysis did not have a publication bias. CONCLUSIONS The results from this meta-analysis support the hypothesis that alcohol consumption can increase the risk of gastric cancer; suggesting that effective moderation of alcohol drinking may reduce the risk of gastric cancer.

摘要

背景 我们试图通过荟萃分析来确定饮酒与胃癌风险之间的关系。

材料与方法 对Medline进行系统检索，以找出所有已发表的关于饮酒与胃癌相关风险的报告。最初我们检索到2494项研究，但在应用纳入和排除标准后，仅发现10项研究符合我们的荟萃分析条件。

结果 我们的荟萃分析表明，饮酒会增加患胃癌的风险，优势比（OR）为1.39（95%置信区间1.20 - 1.61）。此外，亚组分析表明，只有来自瑞典的一项巢式病例对照报告不支持这一观察结果。适度饮酒和大量饮酒的亚组分析也证实，饮酒会增加患胃癌的风险。发表偏倚分析（Begg检验和Egger检验）显示p值大于0.05，表明我们分析中纳入的10篇文章不存在发表偏倚。

结论 这项荟萃分析的结果支持饮酒会增加患胃癌风险这一假设；这表明有效适度饮酒可能会降低胃癌风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d60/5256369/ca9da36faac1/medscimonit-23-238-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d60/5256369/661d9cf2fb0d/medscimonit-23-238-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d60/5256369/535894356c65/medscimonit-23-238-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d60/5256369/f963b60e0f53/medscimonit-23-238-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d60/5256369/ca9da36faac1/medscimonit-23-238-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d60/5256369/32c381816c29/medscimonit-23-238-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d60/5256369/38ae6f937300/medscimonit-23-238-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d60/5256369/13bdc08f01e8/medscimonit-23-238-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d60/5256369/661d9cf2fb0d/medscimonit-23-238-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d60/5256369/ca9da36faac1/medscimonit-23-238-g007.jpg

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