Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Student Research Committee, Department of Medical Biotechnology, School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Curr Mol Med. 2024;24(10):1250-1268. doi: 10.2174/1566524023666230818093016.
The application of monoclonal antibodies and antibody fragments with the advent of recombinant antibody technology has made notable progress in clinical trials to provide a regulated drug release and extra targeting to the special conditions in the function site. Modification of antibodies has facilitated using mAbs and antibody fragments in numerous models of therapeutic and detection utilizations, such as stimuliresponsive systems. Antibodies and antibody derivatives conjugated with diverse stimuliresponsive materials have been constructed for drug delivery in response to a wide range of endogenous (electric, magnetic, light, radiation, ultrasound) and exogenous (temperature, pH, redox potential, enzymes) stimuli. In this report, we highlighted the recent progress on antibody-conjugated stimuli-responsive and dual/multi-responsive systems that affect modern medicine by improving a multitude of diagnostic and treatment strategies.
随着重组抗体技术的出现，单克隆抗体和抗体片段的应用在临床试验中取得了显著进展，为功能部位的特殊条件提供了受控的药物释放和额外的靶向。抗体的修饰促进了单抗和抗体片段在治疗和检测应用的多种模型中的使用，例如刺激响应系统。已经构建了与各种刺激响应材料偶联的抗体和抗体衍生物，以用于药物输送，以响应广泛的内源性（电、磁、光、辐射、超声）和外源性（温度、pH 值、氧化还原电位、酶）刺激。在本报告中，我们强调了最近在抗体偶联的刺激响应和双/多响应系统方面的进展，这些系统通过改进多种诊断和治疗策略来影响现代医学。
