Tu Jiawei, Zhang Hui, Yu Jinsui, Liufu Chun, Chen Zhiyi
Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, People's Republic of China,
Onco Targets Ther. 2018 Sep 12;11:5763-5775. doi: 10.2147/OTT.S171019. eCollection 2018.
Immunotherapy provides a new treatment option for cancer. However, it may be therapeutically insufficient if only using the self-immune system alone to attack the tumor without any aiding methods. To overcome this drawback and improve the efficiency of therapy, new treatment methods are emerging. In recent years, ultrasound-mediated microbubble destruction (UMMD) has shown great potential in cancer immunotherapy. Using the combination of ultrasound and targeted microbubbles, molecules such as antigens or genes encoding antigens can be efficiently and specifically delivered into the tumor tissue. This review focuses on the recent progress in the application of UMMD in cancer immunotherapy.
免疫疗法为癌症提供了一种新的治疗选择。然而，如果仅依靠自身免疫系统单独攻击肿瘤而不采用任何辅助方法，其治疗效果可能并不充分。为克服这一缺点并提高治疗效率，新的治疗方法不断涌现。近年来，超声介导的微泡破坏（UMMD）在癌症免疫疗法中显示出巨大潜力。通过将超声与靶向微泡相结合，抗原或编码抗原的基因等分子能够高效、特异性地递送至肿瘤组织。本文综述聚焦于UMMD在癌症免疫疗法应用中的最新进展。
