Kuo Eric J, Sisk Anthony E, Yang Zhiming, Huang Jiaoti, Yeh Michael W, Livhits Masha J
Section of Endocrine Surgery, UCLA David Geffen School of Medicine, 10833 Le Conte Ave, 72-228 CHS, Los Angeles, CA, 90095, USA.
Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Endocr Pathol. 2017 Jun;28(2):152-158. doi: 10.1007/s12022-017-9468-5.
Adrenal teratomas are rare neoplasms and there is limited data on their surgical outcomes and long-term prognosis. We aimed to review our institutional experience and compare this to the existing literature on adrenal teratomas in adults and children. An institutional pathology database was searched for cases of adrenal teratoma (June 1956-July 2016). Clinical and imaging data were abstracted from the medical records and pathology slides were obtained for review. In addition, a PubMed search for "adrenal teratoma" from June 1952 to July 2016 was performed to identify reports of primary adrenal teratoma in patients of all ages. Of 7706 patients who underwent adrenalectomy during the study period at our institution, three patients were identified with adrenal teratoma. Patients were 24, 26, and 29 years of age, respectively. Two patients presented with abdominal pain and two of the three underwent a laparoscopic adrenalectomy. A pathologic examination revealed mature cystic teratomas that frequently displayed well-differentiated respiratory, digestive, and squamous epithelia. Eighteen case reports in the literature were identified in patients 17-61 years of age. Patients presented most frequently with abdominal or flank pain (63.6%). Median tumor diameter was 9.0 cm and tumors were frequently left-sided (81.8%), cystic (63.6%), and calcified (72.7%) on either radiologic or pathologic examination. Primary adrenal teratomas are rare neoplasms that typically present as large, left-sided nodules with cystic and calcified components seen radiographically. Although the data are limited, they are generally amenable to laparoscopic resection and have a very favorable prognosis.
肾上腺畸胎瘤是罕见的肿瘤，关于其手术结果和长期预后的数据有限。我们旨在回顾我们机构的经验，并将其与现有关于成人和儿童肾上腺畸胎瘤的文献进行比较。在机构病理数据库中检索肾上腺畸胎瘤病例（1956年6月至2016年7月）。从病历中提取临床和影像数据，并获取病理切片进行复查。此外，对1952年6月至2016年7月期间的PubMed进行“肾上腺畸胎瘤”检索，以确定各年龄段患者原发性肾上腺畸胎瘤的报告。在我们机构研究期间接受肾上腺切除术的7706例患者中，有3例被确诊为肾上腺畸胎瘤。患者分别为24岁、26岁和29岁。2例患者表现为腹痛，3例中有2例接受了腹腔镜肾上腺切除术。病理检查显示为成熟的囊性畸胎瘤，常表现为分化良好的呼吸、消化和鳞状上皮。文献中确定了18例年龄在17 - 61岁患者的病例报告。患者最常见的表现是腹痛或侧腹痛（63.6%）。肿瘤中位直径为9.0 cm，在影像学或病理检查中，肿瘤常位于左侧（81.8%），为囊性（63.6%）且有钙化（72.7%）。原发性肾上腺畸胎瘤是罕见的肿瘤，通常表现为大的、位于左侧的结节，影像学上可见囊性和钙化成分。虽然数据有限，但它们一般适合腹腔镜切除，且预后非常良好。
