Alahdal Arwa, Bahkali Manal, Abu-Ouf Noran M, Alturkustani Murad
Pediatrics, King Abdulaziz University, Jeddah, SAU.
Pathology, King Abdulaziz University, Jeddah, SAU.
Cureus. 2023 Jul 3;15(7):e41332. doi: 10.7759/cureus.41332. eCollection 2023 Jul.
We report the first known case of an adrenal teratoma containing a Wilms tumor component, in a 12-month-old girl with Trisomy 21. Despite adrenal teratomas being relatively uncommon, this particular instance raises interesting questions regarding the tumor origin, given the coexistence of both a teratoma and a Wilms tumor. Two main theories of development have been hypothesized, one of which suggests that the Wilms tumor may develop from a primary teratoma and the other proposing that the teratoma could originate from a primary Wilms tumor. Our case study leans toward the former, as the majority of the tumor displayed characteristics of a typical mature teratoma, with the Wilms component discovered as an incidental finding. Successful surgical intervention led to the gross total resection of the tumor. Twelve months post-resection, the patient remains free of recurrence. This report contributes to our understanding of these rare tumor types and underlines the importance of identifying the primary tumor to ensure appropriate management and treatment.
我们报告了首例已知的肾上腺畸胎瘤合并肾母细胞瘤成分的病例，患者为一名患有21三体综合征的12个月大女孩。尽管肾上腺畸胎瘤相对少见，但鉴于畸胎瘤和肾母细胞瘤同时存在，这一特殊病例引发了关于肿瘤起源的有趣问题。目前已提出两种主要的发育理论，一种认为肾母细胞瘤可能由原发性畸胎瘤发展而来，另一种则认为畸胎瘤可能起源于原发性肾母细胞瘤。我们的病例研究倾向于前者，因为肿瘤的大部分表现出典型成熟畸胎瘤的特征，肾母细胞瘤成分是偶然发现的。成功的手术干预实现了肿瘤的全切。切除术后12个月，患者未复发。本报告有助于我们对这些罕见肿瘤类型的理解，并强调了识别原发性肿瘤以确保适当管理和治疗的重要性。
