Zhou Liang, Pan Xiang, He Tao, Lai Yulin, Li Wenhua, Hu Yiming, Ni Liangchao, Yang Shangqi, Chen Yun, Lai Yongqing
Department of Urology, Guangzhou Medical University, Guangzhou, Guangdong 511436, P.R. China.
Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Mol Clin Oncol. 2018 Oct;9(4):437-442. doi: 10.3892/mco.2018.1687. Epub 2018 Aug 1.
Primary adrenal teratoma is a rare type of cancer. Of the 338 patients who underwent adrenalectomy during this study, only 2 (aged 69 and 29 years) were diagnosed with adrenal teratoma and underwent laparoscopic retroperitoneal adrenalectomy. For the purposes of the present study, the term 'adrenal teratoma' was searched in the PubMed database, and 237 articles published between June 1952 and March 2017 were retrieved. However, we were only able to identify 10 relevant studies. In total, these studies reported a series of 18 cases of primary adrenal teratoma in patients aged >16 years, another 8 cases of adult adrenal retroperitoneal teratoma, and 7 cases of adrenal teratoma in children aged <16 years. In the 18 cases aged >16 years, the age range was 17-61 years (mean ± standard deviation, 33.06±15.47 years), the median tumor diameter was 8.25 cm and 13 patients (72.22%) were female. Almost all patients underwent laparoscopic surgery between 2006 and 2017 (75%). Among the 7 cases of adrenal teratoma in children under the age of 16 years, 5 cases (71.43%) were male, the median tumor diameter was 10 cm, the oldest patient was aged 8 years, 5 cases (71.43%) were selected for open surgical resection of the tumor, and 5 cases (71.43%) were followed up without recurrence or death. These data indicate that primary adrenal teratomas in children are rarer compared with adults. Although the data are limited, it was observed that the clinical symptoms of primary adrenal teratoma are not typical, the preferred treatment is retroperitoneal laparoscopic surgery, and the prognosis is favorable. The aim of the present study was to elucidate the clinical characteristics associated with primary adrenal teratoma, in order to further raise awareness of this rare disease.
原发性肾上腺畸胎瘤是一种罕见的癌症类型。在本研究期间接受肾上腺切除术的338例患者中，仅有2例（年龄分别为69岁和29岁）被诊断为肾上腺畸胎瘤并接受了腹腔镜腹膜后肾上腺切除术。为了本研究的目的，在PubMed数据库中检索了“肾上腺畸胎瘤”一词，检索到1952年6月至2017年3月期间发表的237篇文章。然而，我们仅能识别出10项相关研究。这些研究总共报告了一系列18例年龄大于16岁的原发性肾上腺畸胎瘤患者、另外8例成人肾上腺腹膜后畸胎瘤患者以及7例年龄小于16岁的儿童肾上腺畸胎瘤患者。在18例年龄大于16岁的患者中，年龄范围为17 - 61岁（平均±标准差，33.06±15.47岁），肿瘤中位直径为8.25 cm，13例患者（72.22%）为女性。几乎所有患者在2006年至2017年期间接受了腹腔镜手术（75%）。在7例16岁以下儿童肾上腺畸胎瘤患者中，5例（71.43%）为男性，肿瘤中位直径为10 cm，年龄最大的患者为8岁，5例（71.43%）患者选择了开放性肿瘤切除术，5例（71.43%）患者接受了随访，无复发或死亡情况。这些数据表明，与成人相比，儿童原发性肾上腺畸胎瘤更为罕见。尽管数据有限，但观察到原发性肾上腺畸胎瘤的临床症状不典型，首选治疗方法是腹膜后腹腔镜手术，且预后良好。本研究的目的是阐明与原发性肾上腺畸胎瘤相关的临床特征，以便进一步提高对这种罕见疾病的认识。
