通过钌催化的叔烯基乙酸酯的烯丙基胺化反应实现α,α-二取代烯丙基胺的区域选择性构建。
Regioselective Construction of α,α-Disubstituted Allylic Amines by the Ruthenium-Catalyzed Allylic Amination of Tertiary Allylic Acetates.
机构信息
Department of Chemistry, College of Humanities & Sciences, Nihon University , Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan.
出版信息
Org Lett. 2017 Feb 3;19(3):504-507. doi: 10.1021/acs.orglett.6b03672. Epub 2017 Jan 17.
PMID:28094972
Abstract
The ruthenium-catalyzed regioselective allylic amination of tertiary allylic acetates with several types of amines has been accomplished. The reaction was effectively catalyzed by Cp*RuCl/5,5'-dimethyl-2,2'-bipyridine or its related ruthenium catalyst systems, and α,α-disubstituted allylic amines were formed as a single regioisomer in moderate to high yields.
摘要
钌催化的三级烯丙基乙酸酯与多种胺的区域选择性烯丙基胺化反应已经完成。反应在 Cp*RuCl/5,5'-二甲基-2,2'-联吡啶或其相关的钌催化剂体系的有效催化下进行，得到中等至高产率的α,α-二取代烯丙基胺作为单一区域异构体。
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