Le Thai Van Thanh, Nguyen Phuong Thao, Le Vi Anh, Ta Quoc Hung, Zevini Alessandra, Martinelli Daniela, Barini Riccardo
Department of Dermatology and Skin Aesthetics, University Medical Center at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Department of Dermatology and Venereology, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Lasers Med Sci. 2025 Apr 23;40(1):209. doi: 10.1007/s10103-025-04453-4.
Skin rejuvenation is a vital aspect of dermatology aimed at countering intrinsic and extrinsic aging effects, such as wrinkles, dyspigmentation, and texture irregularities. This study evaluates the efficacy and safety of the fractional 1064 nm Nd:YAG picosecond laser in a Vietnamese cohort, addressing unique challenges posed by Asian skin's high melanin content. 44 Vietnamese participants treated at the University Medical Center of Ho Chi Minh City for facial skin rejuvenation were retrospectively analyzed. Outcomes were assessed via standardized imaging and patient-reported satisfaction scores, with statistical analyses applied to evaluate changes in skin indices and identify epidemiological correlations. Measurements using the VISIA system indicated statistically significant reductions in wrinkles, spots, and texture irregularities starting from the first month of treatment (p < 0.01) and sustained through three months (p < 0.0001). Adverse effects were minimal, with transient erythema being the most common (68.18%), and pain levels were generally mild to moderate. Epidemiological analysis revealed that prolonged sun exposure adversely affected UV spot improvement (p = 0.01), while consistent mask-wearing correlated with enhanced outcomes for pigmentation reduction (p = 0.03). This study underscores the fractional 1064 nm Nd:YAG picosecond laser's effectiveness as a safe and versatile tool for skin rejuvenation, particularly for Asian populations prone to post-inflammatory hyperpigmentation. Recommendations for consistent photoprotection and addressing environmental factors further optimize results. Future studies should explore long-term outcomes and comparative efficacy with alternative modalities.
皮肤年轻化是皮肤科的一个重要方面，旨在对抗内在和外在的衰老影响，如皱纹、色素沉着和质地不均。本研究评估了1064纳米Nd:YAG皮秒分数激光在越南人群中的疗效和安全性，探讨了亚洲皮肤高黑色素含量带来的独特挑战。对在胡志明市大学医学中心接受面部皮肤年轻化治疗的44名越南参与者进行了回顾性分析。通过标准化成像和患者报告的满意度评分评估结果，应用统计分析来评估皮肤指标的变化并确定流行病学相关性。使用VISIA系统进行的测量表明，从治疗的第一个月开始，皱纹、斑点和质地不均就有统计学上的显著减少（p < 0.01），并持续到三个月（p < 0.0001）。不良反应最小，最常见的是短暂性红斑（68.18%），疼痛程度一般为轻度至中度。流行病学分析显示，长期日晒对紫外线斑点的改善有不利影响（p = 0.01），而持续佩戴口罩与色素沉着减少的更好效果相关（p = 0.03）。本研究强调了1064纳米Nd:YAG皮秒分数激光作为一种安全且通用的皮肤年轻化工具的有效性，特别是对于易发生炎症后色素沉着的亚洲人群。持续进行光防护和应对环境因素的建议可进一步优化效果。未来的研究应探索长期结果以及与其他治疗方式的比较疗效。
