Micali Nadia, Martini Maria G, Thomas Jennifer J, Eddy Kamryn T, Kothari Radha, Russell Ellie, Bulik Cynthia M, Treasure Janet
Eating and Weight Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
BMC Med. 2017 Jan 17;15(1):12. doi: 10.1186/s12916-016-0766-4.
Eating disorders (EDs) are common amongst women; however, no research has specifically investigated the lifetime/12-month prevalence of eating disorders amongst women in mid-life (i.e., fourth and fifth decade of life) and the relevant longitudinal risk factors. We aimed to investigate the lifetime and 12-month prevalence of EDs and lifetime health service use and to identify childhood, parenting, and personality risk factors.
This is a two-phase prevalence study, nested within an existing longitudinal community-based sample of women in mid-life. A total of 5658 women from the UK Avon Longitudinal Study of Parents and Children (ALSPAC; enrolled 20 years earlier) participated. ED diagnoses were obtained using validated structured interviews. Weighted analyses were carried out accounting for the two-phase methodology to obtain prevalence figures and to carry out risk factor regression analyses.
By mid-life, 15.3% (95% confidence intervals, 13.5-17.4%) of women had met criteria for a lifetime ED. The 12-month prevalence of EDs was 3.6%. Childhood sexual abuse was prospectively associated with all binge/purge type disorders and an external locus of control was associated with binge-eating disorder. Better maternal care was protective for bulimia nervosa. Childhood life events and interpersonal sensitivity were associated with all EDs.
By mid-life a significant proportion of women will experience an ED, and few women accessed healthcare. Active EDs are common in mid-life, both due to new onset and chronic disorders. Increased awareness of the full spectrum of EDs in this stage of life and adequate service provision is important. This is the first study to investigate childhood and personality risk factors for full threshold and sub-threshold EDs and to identify common predictors for full and sub-threshold EDs. Further research should clarify the role of preventable risk factors on both full and sub-threshold EDs.
饮食失调在女性中很常见;然而,尚无研究专门调查中年女性(即40岁和50岁)饮食失调的终生患病率/12个月患病率以及相关的纵向风险因素。我们旨在调查饮食失调的终生患病率和12个月患病率以及终生医疗服务利用情况,并确定童年、养育方式和人格风险因素。
这是一项两阶段患病率研究,嵌套于现有的基于社区的中年女性纵向样本中。共有来自英国埃文亲子纵向研究(ALSPAC;20年前入组)的5658名女性参与。使用经过验证的结构化访谈获得饮食失调诊断。考虑到两阶段方法进行加权分析,以获得患病率数据并进行风险因素回归分析。
到中年时,15.3%(95%置信区间,13.5 - 17.4%)的女性符合终生饮食失调的标准。饮食失调的12个月患病率为3.6%。童年期性虐待与所有暴饮暴食/清除型障碍呈前瞻性关联,而外部控制点与暴饮暴食障碍有关。更好的母亲关怀对神经性贪食症有保护作用。童年生活事件和人际敏感性与所有饮食失调都有关联。
到中年时,相当一部分女性会经历饮食失调,且很少有女性获得医疗保健服务。活跃的饮食失调在中年很常见,这既有新发疾病也有慢性疾病的原因。提高对这一生命阶段饮食失调全貌的认识并提供充分的服务很重要。这是第一项调查完全阈值和亚阈值饮食失调的童年和人格风险因素,并确定完全阈值和亚阈值饮食失调共同预测因素的研究。进一步的研究应阐明可预防风险因素在完全阈值和亚阈值饮食失调中的作用。