Williams D E, Moore R E, Paul V J
Department of Chemistry, University of Hawaii Manoa, Honolulu 96822.
J Nat Prod. 1989 Jul-Aug;52(4):732-9. doi: 10.1021/np50064a011.
The major cytotoxic metabolites of Lissoclinum patella from Pohnpei have been isolated and identified. Most of the cytotoxicity is attributed to a new cyclic peptide, ulithiacyclamide B [4], which is closely related to ulithiacyclamide [1]. The proposed structure of 4 is based on spectroscopic analysis and chemical degradation. Compound 4 exhibits an IC50 of 17 ng/ml against the KB cell line but does not show selective cytotoxicity against solid tumor cells in the Corbett assay.
来自波纳佩岛的扁海鞘（Lissoclinum patella）的主要细胞毒性代谢产物已被分离和鉴定。大部分细胞毒性归因于一种新的环肽——uliithiacyclamide B [4]，它与uliithiacyclamide [1]密切相关。化合物4的推测结构基于光谱分析和化学降解。化合物4对KB细胞系的IC50为17 ng/ml，但在科比特试验中对实体瘤细胞未表现出选择性细胞毒性。
