胃肠道肽对食物摄入的控制：作用机制及肥胖治疗中的可能调节

Prinz Philip, Stengel Andreas

Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.

J Neurogastroenterol Motil. 2017 Apr 30;23(2):180-196. doi: 10.5056/jnm16194.

This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1 via the gut-brain axis. Additionally, we describe the impact of external factors such as intake of different nutrients or stress on the secretion of gastrointestinal peptides. Finally, we highlight possible conservative-physical activity and pharmacotherapy-treatment strategies for obesity as well as surgical techniques such as deep brain stimulation and bariatric surgery also altering these peptidergic pathways.

本综述聚焦于胃肠道分泌的食物摄入调节肽对食欲的控制，即胆囊收缩素、胰高血糖素样肽1、肽YY、胃饥饿素，以及最近发现的通过肠-脑轴起作用的nesfatin-1。此外，我们描述了不同营养素摄入或压力等外部因素对胃肠道肽分泌的影响。最后，我们强调了针对肥胖可能的保守性体育活动和药物治疗策略，以及诸如深部脑刺激和减肥手术等外科技术，这些技术也会改变这些肽能通路。