Igarashi Yasuhiro, Kyoso Takayuki, Kim Youngju, Oikawa Tsutomu
Department of Biotechnology, Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
Department of Nutritional Biochemistry, School of Nutrition and Dietetics, Kanagawa University of Human Services, Kanagawa, Japan.
J Antibiot (Tokyo). 2017 May;70(5):607-610. doi: 10.1038/ja.2016.163. Epub 2017 Jan 18.
A new nucleoside modified by prenylation, simamycin (1), was isolated from the culture broth of a soil-derived Streptomyces sp. Its structure was determined by spectroscopic analysis and chemical synthesis as 5'-O-geranyluridine. Compound 1 induced differentiation of preadipocytes into matured adipocytes.
