Biotechnology Research Center, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
J Nat Prod. 2012 May 25;75(5):986-90. doi: 10.1021/np200742c. Epub 2012 May 14.
Jomthonic acid A (1), a new modified amino acid, was isolated from the culture broth of a soil-derived actinomycete of the genus Streptomyces. The structure and absolute configuration of 1 were determined by spectroscopic analyses and chemical conversion. Jomthonic acid A (1) induced differentiation of preadipocytes into mature adipocytes at 2-50 μM.
乔托诺酸 A（1）是一种新型的修饰氨基酸，从一株来源于土壤的链霉菌属放线菌的发酵液中分离得到。通过光谱分析和化学转化确定了 1 的结构和绝对构型。乔托诺酸 A（1）在 2-50 μM 浓度下诱导前体脂肪细胞向成熟脂肪细胞分化。
