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在严重急性营养不良管理中,世界卫生组织/联合国儿童基金会推荐的治疗性食品与家庭自制治疗性食品的对比:一项随机对照试验。

WHO/UNICEF recommended therapeutic food versus home based therapeutic food in the management of severe acute malnutrition: A randomized controlled trial.

作者信息

Malik Sunil, Mittal Mahima, Kushwaha K P

机构信息

Department of Pediatrics, Subharti Medical College , Meerut, UP , India.

Department of Pediatrics, BRD Medical College , Gorakhpur, UP , India.

出版信息

Sudan J Paediatr. 2016;16(2):21-27.

Abstract

Malnutrition is a major public health problem especially in the developing countries. The objective of the study was to compare WHO/UNICEF recommended therapeutic food with home based therapeutic food in the management of severe acute malnutrition. It was a randomized controlled trial at tertiary care level hospital with nutritional rehabilitation centre. Children (6 month to 5 years) having severe acute malnutrition were included in the study. Group A (n=74 children) was given WHO recommended therapeutic food and group B (n=75 children) was given home based therapeutic food. The mean rate of weight gain, gain in height and increase in mid-upper arm circumference were significantly higher (p<0.05) in the group received home based therapeutic food. Mean duration to achieve target weight was 21.44±3.33 days in group A and 16.28±2.11 days in group B (p<o.ooo1). Group B children had higher rate of increase in urinary creatinine (p<0.0001). Affordability (p<0.0001), Feasibility (p=0.027) and Average frequency of feeding per day (p<0.0001) was found significantly higher in group B. Difficulty in making therapeutic food was significantly low in group B (p<0.05). Both kinds of therapeutic food were effective for the management of severe acute malnutrition, but the home based therapeutic food was found to be more effective. This could be explained by better acceptability in terms of better palatability, more affordability, increased frequency of feeding, and having less difficulty in making.

摘要

营养不良是一个重大的公共卫生问题,尤其是在发展中国家。本研究的目的是比较世界卫生组织/联合国儿童基金会推荐的治疗性食品与家庭自制治疗性食品在重度急性营养不良管理中的效果。这是一项在设有营养康复中心的三级护理医院进行的随机对照试验。研究纳入了6个月至5岁患有重度急性营养不良的儿童。A组(n = 74名儿童)给予世界卫生组织推荐的治疗性食品,B组(n = 75名儿童)给予家庭自制治疗性食品。接受家庭自制治疗性食品的组在体重增加率、身高增长和上臂中部周长增加方面显著更高(p<0.05)。A组达到目标体重的平均时间为21.44±3.33天,B组为16.28±2.11天(p<0.0001)。B组儿童尿肌酐增加率更高(p<0.0001)。发现B组在可承受性(p<0.0001)、可行性(p = 0.027)和每日平均喂养频率(p<0.0001)方面显著更高。B组制作治疗性食品的难度显著较低(p<0.05)。两种治疗性食品对重度急性营养不良的管理均有效,但发现家庭自制治疗性食品更有效。这可以通过在口感更好、更具可承受性、喂养频率增加以及制作难度较小方面具有更好的可接受性来解释。

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Management of severe acute malnutrition in children.儿童重度急性营养不良的管理
Lancet. 2006 Dec 2;368(9551):1992-2000. doi: 10.1016/S0140-6736(06)69443-9.

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