Hall Roy A, Bielefeldt-Ohmann Helle, McLean Breeanna J, O'Brien Caitlin A, Colmant Agathe M G, Piyasena Thisun B H, Harrison Jessica J, Newton Natalee D, Barnard Ross T, Prow Natalie A, Deerain Joshua M, Mah Marcus G K Y, Hobson-Peters Jody
Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Evol Bioinform Online. 2017 Jan 10;12(Suppl 2):35-44. doi: 10.4137/EBO.S40740. eCollection 2016.
Recent advances in virus detection strategies and deep sequencing technologies have enabled the identification of a multitude of new viruses that persistently infect mosquitoes but do not infect vertebrates. These are usually referred to as insect-specific viruses (ISVs). These novel viruses have generated considerable interest in their modes of transmission, persistence in mosquito populations, the mechanisms that restrict their host range to mosquitoes, and their interactions with pathogens transmissible by the same mosquito. In this article, we discuss studies in our laboratory and others that demonstrate that many ISVs are efficiently transmitted directly from the female mosquito to their progeny via infected eggs, and, moreover, that persistent infection of mosquito cell cultures or whole mosquitoes with ISVs can restrict subsequent infection, replication, and transmission of some mosquito-borne viral pathogens. This suggests that some ISVs may act as natural regulators of arboviral transmission. We also discuss viral and host factors that may be responsible for their host restriction.
病毒检测策略和深度测序技术的最新进展，使得人们能够鉴定出大量持续感染蚊子但不感染脊椎动物的新病毒。这些病毒通常被称为昆虫特异性病毒（ISV）。这些新型病毒在其传播方式、在蚊子种群中的持续性、将宿主范围限制在蚊子的机制以及它们与同一蚊子传播的病原体的相互作用方面引起了相当大的关注。在本文中，我们讨论了我们实验室和其他实验室的研究，这些研究表明，许多ISV可通过受感染的卵从雌蚊直接有效地传播给它们的后代，此外，用ISV持续感染蚊子细胞培养物或整个蚊子可限制某些蚊媒病毒病原体随后的感染、复制和传播。这表明一些ISV可能作为虫媒病毒传播的天然调节剂。我们还讨论了可能导致其宿主限制的病毒和宿主因素。
