Saraei Mehrzad, Ghaderi Yosef, Mosavi Tahereh, Shahnazi Mojtaba, Nassiri-Asl Marjan, Jahanihashemi Hassan
Dept. of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran; Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Dept. of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Iran J Parasitol. 2016 Apr-Jun;11(2):226-231.
is the most common parasite causing latent cerebral infections in human. It has been shown that some anti-psychotic drugs are able to inhibit the proliferation of the parasite in in vitro study. There is very limited data regarding the inhibitory effect of anti-psychotics on Toxoplasma in in vivo. In this study, we evaluated anti- activity of fluphenazine and thioridazine drugs on in mice.
Mice were divided into six groups: Control, sesame as vehicle, thioridazine 10 mg/kg, thioridazine 20 mg/kg, fluphenazine 0.06 mg/kg and fluphenazine 0.6 mg/kg. They were inoculated intraperitoneally with brain suspension containing tissue cysts of Tehran strain. Two months after inoculation, the number of cysts in crushed smears of mice brain were counted microscopically and considered as an indicator of anti- activity. This work has conducted in Qazvin, central Iran, 2014.
Our study showed that fluphenazine and thioridazine could not significantly inhibit the brain cystogenesis of in mice. However, the number of brain cysts was less at higher dose compared to lower doses for both drugs.
Further studies need to clear the mechanism of different structure of anti-psychotic drugs on activity of .
是人类潜伏性脑感染最常见的寄生虫。体外研究表明，一些抗精神病药物能够抑制该寄生虫的增殖。关于抗精神病药物在体内对弓形虫的抑制作用的数据非常有限。在本研究中，我们评估了氟奋乃静和硫利达嗪药物对小鼠体内弓形虫的抗虫活性。
将小鼠分为六组：对照组、以芝麻油为赋形剂组、硫利达嗪10mg/kg组、硫利达嗪20mg/kg组、氟奋乃静0.06mg/kg组和氟奋乃静0.6mg/kg组。给它们腹腔注射含有德黑兰株组织包囊的脑悬液。接种两个月后，显微镜下计数小鼠脑压碎涂片上的包囊数量，并将其作为抗虫活性的指标。这项工作于2014年在伊朗中部加兹温进行。
我们的研究表明，氟奋乃静和硫利达嗪不能显著抑制小鼠脑内包囊的形成。然而，两种药物较高剂量组的脑包囊数量均低于较低剂量组。
需要进一步研究以明确抗精神病药物不同结构对弓形虫活性的作用机制。
