Huang Zheng, Shi Songsheng, Qiu Haixia, Li Desheng, Zou Jian, Hu Shaoshan
Fujian Normal University , MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, 8 Shangsan Road, Fuzhou 350007, China.
Fujian Medical University , Union Hospital, Department of Neurosurgery, 29 Xinquan Road, Fuzhou 350001, China.
Neurophotonics. 2017 Jan;4(1):011011. doi: 10.1117/1.NPh.4.1.011011. Epub 2017 Jan 12.
Surgical removal of tumor mass is a common approach in the management of brain tumors. However, the precise delineation of normal tissue from tumor tissue for a complete resection of tumor mass in brain tumor surgery remains a difficult task for neurosurgeons. Aminolevulinic acid (ALA)-mediated exgogenous fluorescence of protoporphyrin IX (PpIX) is a sensitive approach for tumor imaging. Recent studies suggest that the use of ALA/PpIX-mediated fluorescence-guided resection (FGR) or fluorescence-guided surgery can enable more accurate and complete resection of brain tumors, especially when used in quantitative fashion. This review will highlight the current progress in PpIX-mediated FGR and discuss technical challenges in intraoperative quantification of intracellular PpIX fluorescence during FGR of brain tumor.
手术切除肿瘤块是脑肿瘤治疗中的常见方法。然而，在脑肿瘤手术中，精确区分正常组织和肿瘤组织以实现肿瘤块的完全切除，对神经外科医生来说仍然是一项艰巨的任务。氨基乙酰丙酸（ALA）介导的原卟啉IX（PpIX）外源性荧光是一种敏感的肿瘤成像方法。最近的研究表明，使用ALA/PpIX介导的荧光引导切除术（FGR）或荧光引导手术能够更准确、更完整地切除脑肿瘤，尤其是以定量方式使用时。本综述将重点介绍PpIX介导的FGR的当前进展，并讨论脑肿瘤FGR过程中细胞内PpIX荧光术中定量的技术挑战。
