Ansari Zafar Masood, Nasiruddin Mohammad, Khan Rahat Ali, Haque Shahzad Faizul
Department of Pharmacology, J. N. Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Department of Medicine, J. N. Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Saudi J Kidney Dis Transpl. 2017 Jan-Feb;28(1):9-14. doi: 10.4103/1319-2442.198093.
This study aims to evaluate efficacy and safety of Nigella sativa oil supplementation in patients with chronic kidney disease Stage 3 and 4 due to diabetic nephropathy. It was a prospective, comparative, and open-label study. Patients were randomized into two groups. Group 1 (Control) received conservative management of diabetic nephropathy, whereas Group 2 (Test) received N. sativa oil (2.5 mL, once daily and per orally) along with conservative management for 12 weeks. Blood glucose, hemogram, and kidney function test were done at 0, 6, and 12 weeks of treatment. Significance of differences between pre- and post-treatment values in each group was assessed using Student's paired t-test and between the groups using unpaired t-test. We found a drop in blood glucose, serum creatinine, blood urea, and 24 h total urinary protein levels and a rise in glomerular filtration rate, 24 h total urinary volume, and hemoglobin level in the treatment group compared to the control group.
本研究旨在评估补充黑种草籽油对3期和4期糖尿病肾病所致慢性肾脏病患者的疗效和安全性。这是一项前瞻性、对比性、开放标签研究。患者被随机分为两组。第1组（对照组）接受糖尿病肾病的保守治疗，而第2组（试验组）在接受保守治疗的同时，口服黑种草籽油（2.5 mL，每日1次），共12周。在治疗的0、6和12周时进行血糖、血常规和肾功能检查。每组治疗前后值之间差异的显著性采用配对t检验评估，组间差异采用非配对t检验评估。我们发现，与对照组相比，治疗组的血糖、血清肌酐、血尿素和24小时总尿蛋白水平下降，肾小球滤过率、24小时总尿量和血红蛋白水平上升。
