HIV阴性患者的血管肉瘤与HHV-8无关。
Angiosarcoma in HIV-negative patients is not associated with HHV-8.
作者信息
Avancini João, Sanches José Antonio, Cherubim Andre Pires Zanata, Pazzini Renato, Oliveira Cristina Mendes de, Sumita Laura Masami, Valente Neusa Yuriko Sakai, Pannuti Claudio Sergio, Festa Cyro
机构信息
Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
出版信息
An Bras Dermatol. 2016 Nov-Dec;91(6):738-741. doi: 10.1590/abd1806-4841.20164730.
BACKGROUND
: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined.
OBJECTIVE
: To investigate the relationship between the presence of HHV-8 and angiosarcoma.
METHODS
: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls.
RESULTS
: While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was.
CONCLUSION
: These findings support most previous studies that found no association between HHV-8 and angiosarcoma.
背景
血管肉瘤是一种起源于血管或淋巴管的侵袭性恶性肿瘤。疱疹病毒8（HHV-8）是疱疹家族的一员，对内皮细胞具有嗜性，并且已被证明可诱导血管肿瘤，如卡波西肉瘤。HHV-8在血管肉瘤发病机制中的作用尚未明确。
目的
研究HHV-8的存在与血管肉瘤之间的关系。
方法
在本研究中，该团队使用来自流行性卡波西肉瘤患者的样本作为对照，通过聚合酶链反应确定HHV-8的存在，并研究其与血管肉瘤之间的关系。
结果
所有流行性卡波西肉瘤对照病例的HHV-8均为阳性，而血管肉瘤病例均为阴性。
结论
这些发现支持了大多数先前的研究，即未发现HHV-8与血管肉瘤之间存在关联。
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