van de Graaf Rob A, Grüne Frank, Hoeks Sanne E, Ten Raa Sander, Stolker Robert Jan, Verhagen Hence J M, van Lier Felix
1 Department of Anesthesiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
2 Department of Vascular surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.
Vasc Endovascular Surg. 2017 Jan;51(1):23-27. doi: 10.1177/1538574416683755. Epub 2016 Dec 15.
Compared to open thoracoabdominal aortic aneurysm (TAAA) repair, hybrid repair is thought to be less invasive with better perioperative outcomes. Due to the extent of the operation and long recovery period, studying perioperative results may not be sufficient for evaluation of the true treatment effect. The aim of this study is to evaluate 1-year mortality and morbidity in patients with TAAA undergoing hybrid repair.
In a retrospective cohort study, all medical records of patients undergoing hybrid repair for TAAA at the Erasmus University Medical Center between January 2007 and January 2015 were studied. Primary outcome measures were 30-day and 1-year mortality. Secondary outcome measures included major in-hospital postoperative complications.
A total of 15 patients were included. All-cause mortality was 33% (5 of the 15) at 30 days and 60% (9 of the 15) at 1 year. Aneurysm-related mortality was 33% (5 of the 15) and 53% (8 of the 15) at 30-day and 1-year follow-up, respectively, with colon ischemia being the most common cause of death. Major complication rate was high: myocardial infarction in 2 (13%) cases, acute kidney failure in 5 (33%) cases, bowel ischemia in 3 (20%) cases, and spinal cord ischemia in 1 (7%) case.
The presumed less invasive nature of hybrid TAAA repair does not seem to result in lower complication rates. The high mortality rate at 30 days continues to rise dramatically thereafter, suggesting that 1-year mortality is a more useful clinical parameter to use in preoperative decision-making for this kind of repair.
与开放性胸腹主动脉瘤(TAAA)修复术相比,杂交修复术被认为创伤较小,围手术期结果更好。由于手术范围和恢复周期较长,研究围手术期结果可能不足以评估真正的治疗效果。本研究的目的是评估接受杂交修复术的TAAA患者的1年死亡率和发病率。
在一项回顾性队列研究中,对2007年1月至2015年1月期间在伊拉斯姆斯大学医学中心接受TAAA杂交修复术的患者的所有病历进行了研究。主要结局指标为30天和1年死亡率。次要结局指标包括术后主要住院并发症。
共纳入15例患者。30天时全因死亡率为33%(15例中的5例),1年时为60%(15例中的9例)。30天和1年随访时,动脉瘤相关死亡率分别为33%(15例中的5例)和53%(15例中的8例),结肠缺血是最常见的死亡原因。主要并发症发生率较高:心肌梗死2例(13%),急性肾衰竭5例(33%),肠缺血3例(20%),脊髓缺血1例(7%)。
杂交TAAA修复术假定的微创性质似乎并未导致较低的并发症发生率。30天时的高死亡率此后继续大幅上升,这表明1年死亡率是这种修复术前决策中更有用的临床参数。