鼻病毒C、哮喘与病毒受体CDHR3的细胞表面表达
Rhinovirus C, Asthma, and Cell Surface Expression of Virus Receptor CDHR3.
作者信息
Palmenberg Ann C
机构信息
Institute for Molecular Virology and Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA
出版信息
J Virol. 2017 Mar 13;91(7). doi: 10.1128/JVI.00072-17. Print 2017 Apr 1.
Abstract
Human rhinoviruses (RVs) of the A, B, and C species are defined agents of the common cold. But more than that, RV-A and RV-C are the dominant causes of hospitalization category infections in young children, especially those with asthma. The use of cadherin-related family member 3 (CDHR3) by RV-C as its cellular receptor creates a direct phenotypic link between human genetics (G versus A alleles cause Cys529 versus Tyr529 protein variants) and the efficiency with which RV-C can infect cells. With a lower cell surface display density, the human-specific Cys529 variant apparently confers partial protection from the severest virus-induced asthma episodes. Selective pressure favoring the Cys529 codon may have coemerged with the evolution of RV-C and helped shape modern human genomes against the virus-susceptible, albeit ancestral Tyr529.
摘要
A、B和C种人类鼻病毒（RVs）是普通感冒的明确致病原。但不仅如此，RV - A和RV - C是幼儿住院类感染的主要原因，尤其是患有哮喘的幼儿。RV - C将钙黏蛋白相关家族成员3（CDHR3）用作其细胞受体，这在人类遗传学（G等位基因与A等位基因分别导致Cys529与Tyr529蛋白变体）和RV - C感染细胞的效率之间建立了直接的表型联系。由于细胞表面展示密度较低，人类特有的Cys529变体显然能为最严重的病毒诱发哮喘发作提供部分保护。有利于Cys529密码子的选择压力可能与RV - C的进化同时出现，并有助于塑造现代人类基因组以抵御尽管是祖传的Tyr529但却易受病毒感染的情况。
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