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结直肠癌的早期诊断。仍无益处?

Early diagnosis in colorectal cancer. Still no benefit?

作者信息

Ratcliffe R, Kiff R S, Kingston R D, Walsh S H, Jeacock J

出版信息

J R Coll Surg Edinb. 1989 Jun;34(3):152-5.

PMID:2810165
Abstract

Time to diagnosis from first symptoms has been assessed in 332 patients with colorectal cancer treated by the three general surgeons in Trafford Health Authority. When compared with other series, delay to diagnosis has been shortened, particular general practitioner and hospital delay. Fewer patients presented as emergencies and a greater proportion of patients had early-stage disease. There was no significant difference in delay times between Dukes' stage B and C patients but there was a significant difference in survival at 2 years between these two stages. Delay times for patients with risk factors, family histories or diverticular disease were not significantly different from times in patients without these factors.

摘要

对特拉福德卫生局的三位普通外科医生治疗的332例结直肠癌患者从出现首发症状到确诊的时间进行了评估。与其他系列研究相比,确诊延迟时间缩短了,尤其是全科医生和医院延误时间。以急诊就诊的患者减少,更多患者患有早期疾病。Dukes B期和C期患者的延迟时间没有显著差异,但这两个阶段患者的2年生存率存在显著差异。有危险因素、家族史或憩室病患者的延迟时间与无这些因素患者的延迟时间无显著差异。

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1
Early diagnosis in colorectal cancer. Still no benefit?结直肠癌的早期诊断。仍无益处?
J R Coll Surg Edinb. 1989 Jun;34(3):152-5.
2
Early diagnosis in colorectal cancer still no benefit?早期诊断对结直肠癌仍无益处?
Ann Chir. 1989;43(7):570-4.
3
For patients with Dukes' B (TNM Stage II) colorectal carcinoma, examination of six or fewer lymph nodes is related to poor prognosis.对于患有杜克B期(TNM分期II期)结直肠癌的患者,检查六个或更少的淋巴结与预后不良有关。
Cancer. 1998 Aug 15;83(4):666-72.
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Multivariate analysis of the prognostic value of CEA and CA 19-9 serum levels in colorectal cancer.结直肠癌中癌胚抗原(CEA)和糖类抗原19-9(CA 19-9)血清水平预后价值的多变量分析
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Preoperative serum levels of CEA and CA 19-9 and their prognostic significance in colorectal carcinoma.结直肠癌患者术前血清癌胚抗原(CEA)和糖类抗原19-9(CA 19-9)水平及其预后意义
Anticancer Res. 1997 Jul-Aug;17(4B):2935-8.
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Delay of diagnosis and treatment of colorectal cancer--a population-based Danish study.结直肠癌诊断与治疗的延迟——一项基于丹麦人群的研究。
Cancer Detect Prev. 2008;32(1):45-51. doi: 10.1016/j.cdp.2008.01.001. Epub 2008 Apr 10.
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[Multivariate analysis of prognostic factors in colorectal cancer patients with different ages].[不同年龄结直肠癌患者预后因素的多因素分析]
Zhonghua Zhong Liu Za Zhi. 2005 Aug;27(8):483-5.
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Young age is not a poor prognostic marker in colorectal cancer.年轻并非结直肠癌预后不良的标志。
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A paradox explained? Patients with delayed diagnosis of symptomatic colorectal cancer have good prognosis.一个悖论得到解释了吗?有症状的结直肠癌诊断延迟的患者预后良好。
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Prophylactic Oophorectomy: Reducing the U.S. Death Rate from Epithelial Ovarian Cancer. A Continuing Debate.预防性卵巢切除术:降低美国上皮性卵巢癌死亡率。一场持续的争论。
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引用本文的文献

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Impact of Colon Cancer Location on the Prognostic Significance of Nutritional Indexes and Inflammatory Markers.结直肠癌部位对营养指标和炎症标志物预后意义的影响。
In Vivo. 2021 Mar-Apr;35(2):1261-1269. doi: 10.21873/invivo.12377.
2
Do comorbidities influence help-seeking for cancer alarm symptoms? A population-based survey in England.共病是否影响对癌症报警症状的寻求帮助?一项基于人群的英格兰调查。
J Public Health (Oxf). 2018 Jun 1;40(2):340-349. doi: 10.1093/pubmed/fdx072.
3
Delay in Presentation, Diagnosis and Treatment for Colorectal Cancer Patients in Jordan.
约旦结直肠癌患者就诊、诊断及治疗的延迟情况
J Gastrointest Cancer. 2016 Mar;47(1):36-46. doi: 10.1007/s12029-015-9783-3.
4
Influences on pre-hospital delay in the diagnosis of colorectal cancer: a systematic review.结直肠癌诊断中院前延迟的影响因素:一项系统综述
Br J Cancer. 2008 Jan 15;98(1):60-70. doi: 10.1038/sj.bjc.6604096. Epub 2007 Dec 4.
5
Management of colorectal cancer.结直肠癌的管理
Qual Health Care. 1998 Jun;7(2):103-8. doi: 10.1136/qshc.7.2.103.
6
Emergency admission for cancer: a matter of survival?癌症急诊入院:关乎生存吗?
Br J Cancer. 1998;77(3):477-84. doi: 10.1038/bjc.1998.76.
7
Lower gastrointestinal bleeding during anticoagulant therapy: a life-saving complication?抗凝治疗期间的下消化道出血:一种危及生命的并发症?
Ann R Coll Surg Engl. 1997 Jan;79(1):38-9.
8
Occurrence and clinical significance of overt blood loss per rectum in the general population and in medical practice.普通人群及医疗实践中直肠显性失血的发生率及临床意义。
Br J Gen Pract. 1994 Jul;44(384):320-5.
9
Rectal examination in general practice.全科医疗中的直肠检查。
BMJ. 1990 Sep 8;301(6750):478-80. doi: 10.1136/bmj.301.6750.478.