Deb Mohit L, Borpatra Paran J, Saikia Prakash J, Baruah Pranjal K
Department of Applied Sciences, GUIST, Gauhati University, Guwahati-781014, Assam, India.
Analytical chemistry division, CSIR-NEIST, Jorhat-785006, India.
Org Biomol Chem. 2017 Feb 7;15(6):1435-1443. doi: 10.1039/c6ob02671k.
Herein we report a microwave assisted Ru(iii)/TBHP-mediated reaction of indoles with tetramethylurea (TMU) synthesizing symmetrical as well as unsymmetrical bis(indolyl)methanes, where TMU acts as a methylenating agent. This is the first report where TMU is used as a methylene source. Moreover, the synthesis of unsymmetrical bis(indolyl)methanes by using a carbon precursor is also reported herein for the first time. Various substituted indoles are used for the reaction. The reaction is high yielding and takes a much shorter time to accomplish compared to the existing methods.
在此，我们报道了一种微波辅助的钌（III）/叔丁基过氧化氢（TBHP）介导的吲哚与四甲基脲（TMU）的反应，该反应合成了对称和不对称的双（吲哚基）甲烷，其中TMU作为亚甲基化剂。这是首次报道使用TMU作为亚甲基源。此外，本文还首次报道了使用碳前驱体合成不对称双（吲哚基）甲烷。各种取代的吲哚用于该反应。与现有方法相比，该反应产率高且完成时间短得多。
