来自金鸡菊的聚乙炔糖苷的分离、表征及抗菌活性
Isolation, characterization and antimicrobial activities of polyacetylene glycosides from Coreopsis tinctoria Nutt.
作者信息
Guo Jia, Wang Ao, Yang Ke, Ding Hao, Hu Yimin, Yang Yumeng, Huang Siqi, Xu Jingguo, Liu Tianxing, Yang Haiyan, Xin Zhihong
机构信息
Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China; College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumqi, People's Republic of China.
出版信息
Phytochemistry. 2017 Apr;136:65-69. doi: 10.1016/j.phytochem.2016.12.023. Epub 2017 Jan 16.
Polyacetylene glycosides, (6Z, 12E)-tetradecadiene-8,10-diyne-1-ol-3(R)-O-β-D-glucopyranoside (trivially named coreoside E) and (6Z, 12E)-tetradecadiene-8,10-diyne-1-ol-3(R)-O-β-L-arabinopyranosyl-(1 → 2)-β-D-glucopyranoside (trivially named coreoside F), were isolated from buds of Coreopsis tinctoria Nutt., together with one known compound, coreoside B. Their chemical structures were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivities. Coreoside E exhibited high levels of antimicrobial activity against Staphylococcus aureus and Bacillus anthracis with minimum inhibitory concentrations of 27 ± 0.27 and 18 ± 0.40 μM, respectively, whereas coreoside F and coreoside B showed weak antimicrobial activity against S. aureus and B. anthracis.
从金鸡菊（Coreopsis tinctoria Nutt.）的芽中分离出了聚乙炔糖苷，即(6Z, 12E)-十四碳二烯-8,10-二炔-1-醇-3(R)-O-β-D-吡喃葡萄糖苷（俗名coreoside E）和(6Z, 12E)-十四碳二烯-8,10-二炔-1-醇-3(R)-O-β-L-阿拉伯吡喃糖基-(1→2)-β-D-吡喃葡萄糖苷（俗名coreoside F），以及一种已知化合物coreoside B。通过广泛的光谱分析并基于它们的化学反应性阐明了它们的化学结构。Coreoside E对金黄色葡萄球菌和炭疽芽孢杆菌表现出高水平的抗菌活性，其最低抑菌浓度分别为27±0.27和18±0.40μM，而coreoside F和coreoside B对金黄色葡萄球菌和炭疽芽孢杆菌显示出较弱的抗菌活性。
Zotero 插件